Document Detail


Natural history of trisomy 18.
MedLine Citation:
PMID:  8795354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that survival in babies with trisomy 18 may be better than previously recognised, and that cardiac surgery may be justified. A population based study spanning seven years in one English health region is presented. The fetal prevalence at 18 weeks was 1 in 4274 and birth prevalence 1 in 8333 live births. Trisomy 18 was detected antenatally in 43% of cases, but almost 90% of those born without a diagnosis were known to be growth retarded in utero. More than 50% of liveborn infants were delivered by caesarean section. The median survival of those born alive was 3 days with no babies living longer than one year. Cardiac malformations were not universal but were present in more than 87% of those for whom there were data. However, in only three cases were cardiac problems implicated in the death of the infants. Cardiac surgery is not likely to improve the survival of infants with trisomy 18 and at present cannot be justified. The most common mode of death was central apnoea.
Authors:
N D Embleton; J P Wyllie; M J Wright; J Burn; S Hunter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  75     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F38-41     Citation Subset:  AIM; IM    
Affiliation:
Department of Paediatric Cardiology, Freeman Hospital NHS Trust, Newcastle upon Tyne.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromosomes, Human, Pair 18*
England / epidemiology
Female
Heart Defects, Congenital / genetics*,  mortality,  surgery
Humans
Infant, Newborn
Male
Pregnancy
Prevalence
Retrospective Studies
Trisomy*
Ultrasonography, Prenatal
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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