Document Detail

Natural history of trisomy 18.
MedLine Citation:
PMID:  8795354     Owner:  NLM     Status:  MEDLINE    
It has been suggested that survival in babies with trisomy 18 may be better than previously recognised, and that cardiac surgery may be justified. A population based study spanning seven years in one English health region is presented. The fetal prevalence at 18 weeks was 1 in 4274 and birth prevalence 1 in 8333 live births. Trisomy 18 was detected antenatally in 43% of cases, but almost 90% of those born without a diagnosis were known to be growth retarded in utero. More than 50% of liveborn infants were delivered by caesarean section. The median survival of those born alive was 3 days with no babies living longer than one year. Cardiac malformations were not universal but were present in more than 87% of those for whom there were data. However, in only three cases were cardiac problems implicated in the death of the infants. Cardiac surgery is not likely to improve the survival of infants with trisomy 18 and at present cannot be justified. The most common mode of death was central apnoea.
N D Embleton; J P Wyllie; M J Wright; J Burn; S Hunter
Related Documents :
590604 - Standards of cleansing and sterilization of infant feeding utensils in the home.
7070334 - Newborn transport in south australia, 1978-80: experience of the queen victoria hospita...
21683184 - Gastric antrum hypertrophy causing outlet obstruction in an infant with congenital diap...
18780604 - Serum insulin-like growth factor-i (igf-i), igf-binding protein-3, and growth hormone l...
10838344 - Perinatal mortality and morbidity rates among singleton, twin, and triplet gestations.
7418504 - The development of visual accommodation during early infancy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  75     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F38-41     Citation Subset:  AIM; IM    
Department of Paediatric Cardiology, Freeman Hospital NHS Trust, Newcastle upon Tyne.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromosomes, Human, Pair 18*
England / epidemiology
Heart Defects, Congenital / genetics*,  mortality,  surgery
Infant, Newborn
Retrospective Studies
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Morbidity during the first year of life in small for gestational age infants.
Next Document:  Postnatal hypothermia and cold stress among newborn infants in Nepal monitored by continuous ambulat...