| Natural history and treatment with ursodiol of gallstones formed during rapid loss of weight in man. | |
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MedLine Citation:
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PMID: 8082507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cholesterol gallstones form frequently among obese patients during rapid loss of weight. The aims of the present study were to determine the short-term natural history of these gallstones and the efficacy of ursodiol for their dissolution. Twenty-two patients whose gallstones had formed during rapid loss of weight were randomized in double-masked fashion to either ursodiol, 1200 mg/day, or placebo for nine months. Ultrasonography of the gallbladder was performed after three and nine months of treatment. All patients without disappearance of their gallstones after nine months received open-label ursodiol for an additional nine months with ultrasonography after three and nine months. Among the patients completing three months of masked treatment, disappearance of gallstones was seen in five of 11 patients who received placebo and four of seven patients who received ursodiol. Only one additional patient of six continuing placebo for nine months experienced disappearance. Neither of two patients continuing ursodiol for nine months had disappearance of gallstones. None of the five patients treated with open-label ursodiol for nine months had disappearance of gallstones. Thus, half of the gallstones that form during rapid loss of weight disappear rapidly once loss of weight ceases; ursodiol may not increase the frequency or rapidity of their disappearance. |
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Authors:
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J W Marks; T Stein; L J Schoenfield |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 39 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-10-13 Completed Date: 1994-10-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1981-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, UCLA School of Medicine. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cholelithiasis / drug therapy*, etiology, ultrasonography Double-Blind Method Female Humans Male Middle Aged Treatment Outcome Ursodeoxycholic Acid / therapeutic use* Weight Loss / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AM 37080/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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128-13-2/Ursodeoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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