| Natural history of stenosis in the iliac arteries in patients with intermittent claudication undergoing clinical treatment. | |
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MedLine Citation:
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PMID: 15654487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Inspite of the long experience with the treatment of intermittent claudication, little is known about the natural history of stenotic lesions in the iliac segment. With the advent of endovascular treatment, this knowledge has become important. METHODS: Fifty-two stenosis, diagnosed using arteriography, in 38 claudicant patients were analyzed. After a minimum time interval of 6 months, a magnetic resonance angiography was performed to determine whether there was arterial occlusion. The primary factors that could influence the progression of a stenosis were analyzed, such as risk factors (smoking, hypertension, diabetes, sex, and age), compliance with clinical treatment, initial degree of stenosis, site of the stenosis, and length of follow-up. RESULTS: The average length of follow-up was 39 months. From the 52 lesions analyzed, 13 (25%) evolved to occlusion. When occlusion occurred, there was clinical deterioration in 63.2% of cases. This association was statistically significant (P = .002). There was no statistically significant association of the progression of the lesion with the degree or site of stenosis, compliance with treatment, or length of follow-up. Patients who evolved to occlusion were younger (P = .02). The logistic regression model showed that the determinant factors for clinical deterioration were arterial occlusion and noncompliance with clinical treatment. CONCLUSIONS: The progression of a stenosis to occlusion, which occurred in 25% of the cases, caused clinical deterioration. Clinical treatment was important, but it did not forestall the arterial occlusion. Prevention of occlusion could be achieved by early endovascular intervention or with the development of drugs that might stabilize the atherosclerotic plaque. |
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Authors:
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Fernando Bocchino Ferrari; Nelson Wolosker; Ruben Aizyn Rosoky; Giuseppe D'Ippolito; Angela Maria Borri Wolosker; Pedro Puech-Leão |
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Publication Detail:
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Type: Journal Article Date: 2005-01-11 |
Journal Detail:
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Title: Revista do Hospital das Clínicas Volume: 59 ISSN: 0041-8781 ISO Abbreviation: Rev Hosp Clin Fac Med Sao Paulo Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415246 Medline TA: Rev Hosp Clin Fac Med Sao Paulo Country: Brazil |
Other Details:
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Languages: eng Pagination: 341-8 Citation Subset: IM |
Affiliation:
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Department of Surgery and Division of Vascular Surgery, Hospital das Clínicas, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Constriction, Pathologic / etiology, radiography Disease Progression Female Follow-Up Studies Humans Iliac Artery* / radiography Intermittent Claudication / complications*, radiography, therapy Logistic Models Magnetic Resonance Angiography Male Middle Aged Prospective Studies Risk Factors Treatment Refusal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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