Document Detail

Natural history of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden.
MedLine Citation:
PMID:  20937998     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the natural history of retinopathy of prematurity (ROP) in 506 extremely preterm infants born before 27 weeks' gestation in Sweden during a 3-year period. METHODS: A national population-based study was performed in Sweden from April 1, 2004, to March 31, 2007. According to the study protocol, initial eye examinations were to be performed at postnatal week 5, and examinations were repeated until the retina was completely vascularized or until criteria for treatment were met. The examinations were to be performed weekly, enabling study of the course and severity of ROP. In infants without ROP or with mild ROP without progression during the latest examinations, further examinations were performed weekly or every other week from postmenstrual age 35 weeks. RESULTS: During the study, 368 infants (72.7%) developed ROP. Postmenstrual age at onset of ROP was significantly related to severity of ROP, even when controlling for gestational age (ie, the earlier the onset of ROP, the higher the risk of developing severe ROP). Site of onset of ROP was significantly related to gestational age at birth. The risk of nasal onset was almost doubled for every week of decrease in gestational age at birth. Nasal onset was associated with severe ROP, even after adjusting for gestational age at birth. CONCLUSION: This population-based study confirms results of the Cryotherapy for Retinopathy of Prematurity study and shows new correlations regarding time and site of onset of ROP, both of which are associated with disease severity.
Dordi Austeng; Karin B M Källen; Ann Hellström; Kristina Tornqvist; Gerd E Holmström
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  128     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2010-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1289-94     Citation Subset:  AIM; IM    
Department of Neuroscience,Uppsala University, 75185 Uppsala, Sweden.
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MeSH Terms
Age of Onset
Disease Progression
Gestational Age*
Infant, Newborn
Infant, Very Low Birth Weight
Premature Birth
Prospective Studies
Retinopathy of Prematurity / diagnosis,  epidemiology*
Sweden / epidemiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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