| Natural history of progressive supranuclear palsy: a clinicopathologic study from a population of brain donors. | |
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MedLine Citation:
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PMID: 16015014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progressive supranuclear palsy (PSP) is the second most common parkinsonian syndrome, characterized by a 'diverse' clinical phenotype. Although several different diagnostic guidelines have been proposed, the early and accurate diagnosis of PSP remains problematic and neuropathology is still considered the 'gold standard'. In order to contribute to the better clinical characterization of PSP, we conducted a postmortem study in a cohort of 22 consecutive PSP brain donors and compared our results with those of previously published reports. Our results further demonstrate and expand the varied clinical picture of PSP. Furthermore, we report associations between older age at onset, early dementia, early falls and smoking with shorter PSP duration. |
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Authors:
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Spiridon Papapetropoulos; Jocely Gonzalez; Deborah C Mash |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-07-05 |
Journal Detail:
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Title: European neurology Volume: 54 ISSN: 0014-3022 ISO Abbreviation: Eur. Neurol. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-09-13 Completed Date: 2005-10-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Copyright Information:
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(c) 2005 S. Karger AG, Basel |
Affiliation:
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Department of Neurology, School of Medicine, University of Miami, Miami, FL 33136, USA. spapapetropoulos@med.miami.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Age of Onset Aged Dementia / etiology Female Humans Male Middle Aged Postural Balance / physiology Smoking / adverse effects Supranuclear Palsy, Progressive / diagnosis*, pathology, physiopathology* |
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