Document Detail

Natural history of primary progressive aphasia.
MedLine Citation:
PMID:  16186529     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To characterize the natural history of primary progressive aphasia (PPA). METHODS: Forty-nine patients (28 women) with newly diagnosed with PPA presenting to a memory disorders clinic between 1992 and 2001 were prospectively evaluated. RESULTS: Median age at onset was 62 years (range 49 to 73 years) and at first visit was 66 years (52 to 80 years). The median duration of follow-up was 4 years (1 to 11 years). Impairments in activities of daily living developed a median of 6 to 7 (2 to 12) years post onset. Seventy-five percent of patients eventually met clinical diagnostic criteria for frontotemporal dementia (FTD), 14% met diagnostic criteria for dementia with Lewy bodies, and 8% developed signs of corticobasal degeneration; 60% of the patients died after a median course of 7 years (3 to 17 years) at a median age of 71 years (56 to 81 years). Patients showing high Mini-Mental State Examination scores, moderate aphasia, and fluent language at first visit subsequently retained greater autonomy in daily life. CONCLUSIONS: Although activities of daily living are well maintained during the first years of the disease, patients with primary progressive aphasia (PPA) may lose autonomy 6 to 7 years after onset. The majority of patients with PPA in the current study developed frontotemporal dementia.
Emilie Le Rhun; Florence Richard; Florence Pasquier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  65     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-27     Completed Date:  2006-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  887-91     Citation Subset:  AIM; IM    
Department of Neurology, Memory Clinic, University Hospital of Lille, France.
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MeSH Terms
Activities of Daily Living*
Age Factors
Age of Onset
Aged, 80 and over
Aphasia, Primary Progressive / epidemiology*,  physiopathology*,  radionuclide imaging
Brain / pathology,  physiopathology,  radionuclide imaging
Cohort Studies
Dementia / epidemiology*,  physiopathology*,  radionuclide imaging
Disease Progression
Magnetic Resonance Imaging
Middle Aged
Mortality / trends
Neuropsychological Tests
Prospective Studies
Time Factors
Tomography, Emission-Computed, Single-Photon

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