| Natural history of primary progressive aphasia. | |
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MedLine Citation:
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PMID: 16186529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To characterize the natural history of primary progressive aphasia (PPA). METHODS: Forty-nine patients (28 women) with newly diagnosed with PPA presenting to a memory disorders clinic between 1992 and 2001 were prospectively evaluated. RESULTS: Median age at onset was 62 years (range 49 to 73 years) and at first visit was 66 years (52 to 80 years). The median duration of follow-up was 4 years (1 to 11 years). Impairments in activities of daily living developed a median of 6 to 7 (2 to 12) years post onset. Seventy-five percent of patients eventually met clinical diagnostic criteria for frontotemporal dementia (FTD), 14% met diagnostic criteria for dementia with Lewy bodies, and 8% developed signs of corticobasal degeneration; 60% of the patients died after a median course of 7 years (3 to 17 years) at a median age of 71 years (56 to 81 years). Patients showing high Mini-Mental State Examination scores, moderate aphasia, and fluent language at first visit subsequently retained greater autonomy in daily life. CONCLUSIONS: Although activities of daily living are well maintained during the first years of the disease, patients with primary progressive aphasia (PPA) may lose autonomy 6 to 7 years after onset. The majority of patients with PPA in the current study developed frontotemporal dementia. |
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Authors:
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Emilie Le Rhun; Florence Richard; Florence Pasquier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology Volume: 65 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-09-27 Completed Date: 2006-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 887-91 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Memory Clinic, University Hospital of Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living* Age Factors Age of Onset Aged Aged, 80 and over Aphasia, Primary Progressive / epidemiology*, physiopathology*, radionuclide imaging Brain / pathology, physiopathology, radionuclide imaging Cohort Studies Comorbidity Dementia / epidemiology*, physiopathology*, radionuclide imaging Disease Progression Female Humans Magnetic Resonance Imaging Male Middle Aged Mortality / trends Neuropsychological Tests Prognosis Prospective Studies Time Factors Tomography, Emission-Computed, Single-Photon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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