| Natural history of physical function in older men with intermittent claudication. | |
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MedLine Citation:
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PMID: 15218465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was undertaken to determine the natural history of physical function in older men limited by intermittent claudication. METHODS: Forty-three men limited by intermittent claudication (mean age, 69 +/- 7 years) were recruited and followed up for 18 months. At baseline the patients reported a history of intermittent claudication for 6.1 +/- 6.1 years, and were able to walk for 1.9 +/- 1.6 blocks before experiencing claudication pain. Measurements during the 18-month study included ankle-brachial index (ABI), calf blood flow, 6-minute walk performance, monitored and self-reported physical activity, self-reported stability while walking, and summary performance score of physical function determined from a 4-m walk test, a chair stand test, and a tandem stand test. RESULTS: Pain-free walking distance during the 6-minute walk test decreased by 22% (P <.05) from baseline (185 +/- 96 m) to follow-up (144 +/- 93 m), and the total 6-minute walk distance decreased by 9% (P <.05), from 368 +/- 106 m to 334 +/- 90 m. Furthermore, monitored physical activity decreased by 31% (P <.05), from 159 +/- 151 kcal/d to 110 +/- 137 kcal/d; self-reported physical activity declined by 27% (P <.05), from 1.5 +/- 1.0 units to 1.1 +/- 0.8 units; tandem stance time declined by 14% (P <.05), from 9.46 +/- 1.83 seconds to 8.12 +/- 2.10 seconds; summary performance score of physical function decreased by 12% (P <.05), from 6.8 +/- 2.4 units to 6.0 +/- 2.4 units; and the percentage of patients reporting ambulatory unsteadiness and stumbling increased from 28% to 43% (P <.05). Calf blood flow measured at rest declined by 18% (P <.05), from 3.72 +/- 1.81 (mL/100 mL(-1)/min(-1)) to 3.04 +/- 1.43 mL/100 mL(-1)/min(-1), whereas ABI did not change (P >.05). CONCLUSION: Older men limited by intermittent claudication experienced decline in ambulatory function, physical activity, physical function, stability, and calf blood flow over 18 months of follow-up, despite no change in ABI. |
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Authors:
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Andrew W Gardner; Polly S Montgomery; Lois A Killewich |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter Volume: 40 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-25 Completed Date: 2004-07-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Affiliation:
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Department of Health and Sport Sciences, University of Oklahoma, Norman 73019, USA. awgardner@ou.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Ankle Blood Pressure / physiology Brachial Artery Diagnostic Techniques, Cardiovascular Disease Progression Humans Intermittent Claudication / physiopathology* Leg / blood supply* Male Pilot Projects Regional Blood Flow Walking / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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K01-00657//PHS HHS; M01-RR-14467/RR/NCRR NIH HHS; P60-AG12583/AG/NIA NIH HHS; R01-AG-16685/AG/NIA NIH HHS |
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