| Natural history and outcome of prenatally diagnosed cystic hygroma. | |
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MedLine Citation:
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PMID: 15614877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To define the outcome in cases of cystic hygroma diagnosed from a routine obstetric population. METHOD: This was a retrospective study of 42 cases of fetal cystic hygroma detected at 11 to 23 weeks' gestation in a routine obstetric population of 25 352 pregnancies. Fetal cystic hygroma was categorized according to position, severity, presence of cardiac defects and Hydrops fetalis. RESULTS: There were 20 (47.6%) cases with aneuploidy (9 trisomies and 11 Turner's syndrome). Major congenital cardiac defects were identified in 12 (28.6%) cases. Regression of the hygroma was noted in 2/20 (10%) of the aneuploid pregnancies and 3/17 (17.6%) of the euploid pregnancies. The majority (90.0%) of the aneuploid fetuses were female. In contrast, 70.58% of the fetuses in the euploid group were male and all the surviving normal babies were also male (n = 3). CONCLUSION: The findings of this study would support invasive prenatal diagnosis for an ultrasound finding of fetal cystic hygroma. Even in euploid pregnancies with cystic hygroma, there is a high mortality with associated abnormalities. The data also suggest a guarded pregnancy prognosis for the finding of fetal cystic hygroma, and that it is improved with spontaneous resolution, especially in male fetuses of normal karyotype. |
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Authors:
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R Ganapathy; M Guven; F Sethna; U Vivekananda; B Thilaganathan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 24 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-28 Completed Date: 2005-04-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 965-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2004 John Wiley & Sons, Ltd. |
Affiliation:
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Feto-Maternal Medicine Unit, Academic Department of Obstetrics and Gynaecology, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Congenital Abnormalities Female Fetal Death Fetal Diseases / ultrasonography Gestational Age Heart Defects, Congenital / complications Humans Lymphangioma, Cystic / genetics, ultrasonography* Male Pregnancy Pregnancy Outcome* Retrospective Studies Trisomy Turner Syndrome Ultrasonography, Prenatal* |
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