Document Detail

Natural history of moyamoya disease: comparison of activity of daily living in surgery and non surgery groups.
MedLine Citation:
PMID:  9409397     Owner:  NLM     Status:  MEDLINE    
The present study was undertaken to reach a clearer understanding of the natural history of Moyamoya disease. Follow-up studies were performed in 88 patients with Moyamoya disease. They were divided into the ischemia group and the hemorrhage group. The activity of daily living (ADL) of each groups were followed up and compared between those who were surgically treated and conservatively managed. Ischemic manifestations were more common in the younger children and tended to be recurrent, whereas hemorrhagic manifestations were more common in the adults. Follow-up duration of the 36 patients, who were surgically treated, ranged from 6 to 86.4 months (mean: 28.8 months). During the follow-up period, ADL was improved in 17 of 31 ischemic Moyamoya patients (55%); the condition was unchanged in nine (29%); and aggravated in five (16%). Follow-up duration of the 52 patients who were managed without surgery ranged from 12 to 216 months (mean: 67.2 months). In 35 patients of the ischemia group, ADL was aggravated in 49% and improved in only 26% during the follow-up period. However, ADL was aggravated in 12% of 17 hemorrhagic patients, but improved in 53%. Our result suggest that indirect revascularization procedures are effective for prevention of recurrent ischemic attacks which is common in pediatric patients. However, the effectiveness of indirect revascularization for hemorrhagic Moyamoya disease is not clear and requires extended follow-up study.
J U Choi; D S Kim; E Y Kim; K C Lee
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  99 Suppl 2     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-18     Completed Date:  1998-02-18     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  S11-8     Citation Subset:  IM    
Department of Neurosurgery, Yonsei University College of Medicine, Seoul, South Korea.
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MeSH Terms
Activities of Daily Living*
Age Distribution
Age of Onset
Cerebral Angiography
Cerebral Revascularization
Cerebrovascular Disorders / complications
Child, Preschool
Follow-Up Studies
Magnetic Resonance Imaging
Middle Aged
Moyamoya Disease / complications,  diagnosis,  surgery*
Severity of Illness Index
Sex Distribution
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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