Document Detail

Natural history of hypertension subtypes in young and middle-age adults.
MedLine Citation:
PMID:  19229194     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The evolution of hypertension (HT) subtypes in young-to-middle-age subjects is unclear.
METHODS: We did a prospective study in 1,141 participants aged 18-45 years from the HARVEST study screened for stage 1 HT, and 101 nonhypertensive subjects of control during a median follow-up of 72.9 months.
RESULTS: At baseline, 13.8% of the subjects were classified as having isolated systolic HT (ISH), 24.8% as having isolated diastolic HT (IDH), and 61.4% as having systolic-diastolic HT (SDH). All hypertensive groups developed sustained HT (clinic blood pressure > or =140/90 mm Hg from two consecutive visits occurring at least after > or =6 months of observation) more frequently than nonhypertensive subjects (P < 0.001 for all) with adjusted odds ratio of 5.2 (95%CI 2.9-9.2) among the SDH subjects, 2.6 (95%CI 1.5-4.5) among the IDH subjects, and 2.2 (95%CI 1.2-4.5) among the ISH subjects. When the definition of HT was based on ambulatory blood pressure (mean daytime blood pressure > or =135/85 mm Hg, n = 798), odds ratios were 5.1 (95%CI 3.1-8.2), 5.6 (95%CI 3.2-9.8), and 3.3 (95%CI 1.7-6.3), respectively. In the fully adjusted logistic model, the risk of ambulatory HT was smaller for the ISH than the IDH (P = 0.049) or SDH (P = 0.053) individuals.
CONCLUSIONS: The present results indicate that young-to-middle-age subjects with ISH have a smaller risk of developing ambulatory HT than either subjects with SDH or IDH. Whether antihypertensive treatment can be postponed for long periods of time in young subjects with mild elevations of clinic systolic BP and low global cardiovascular risk should be examined in further studies.
Francesca Saladini; Francesca Dorigatti; Massimo Santonastaso; Lucio Mos; Fabio Ragazzo; Alessandra Bortolazzi; Mauro Mattarei; Guido Garavelli; Paolo Mormino; Paolo Palatini;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-02-19
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-23     Completed Date:  2009-05-28     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  531-7     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory
Hypertension / etiology,  physiopathology*
Middle Aged
Prospective Studies
Young Adult
G Catania / ; R Da Cortà / ; G Garavelli / ; F Pegoraro / ; S Laurini / ; D D'Este / ; F Dorigatti / ; V Zaetta / ; P Frezza / ; P Bratti / ; D Perkovic / ; C Guarnieri / ; G Cignacco / ; G Zanata / ; M Mattarei / ; T Biasion / ; P Zonzin / ; A Bortolazzi / ; L Mos / ; S Martina / ; O Vriz / ; L Milani / ; C Canali / ; P Dal Ri / ; M Dal Follo / ; G Calconi / ; P Gatti / ; M Santonastaso / ; E Cozzutti / ; R Garbelotto / ; A Mazzer / ; P Palatini /

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