Document Detail


Natural history of food allergy in infants and children in Israel.
MedLine Citation:
PMID:  19119709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Knowledge about the natural history of food allergy, especially sesame, is scarce. OBJECTIVE: To follow the natural history of food allergies in Israel, particularly of sesame allergy. METHODS: The survey was conducted based on clinical records and a detailed questionnaire of children diagnosed as having food allergy. RESULTS: We found 234 children with suspected food allergy. Testing detected 283 allergies in 180 patients (77%) with confirmed diagnosis. The most common allergies were to cow's milk (n = 125), eggs (n = 71), sesame (n = 30), and soy (n = 23). Of those with milk allergy, 69% were IgE mediated (group 1) and 31% were non-IgE mediated (group 2). Group 1 was more likely to have an atopic background than was group 2 (P = .003), whereas group 2 was more likely to have resolution of the allergy (35 of 39 [90%] in group 2 compared with only 32 of 86 [37%] in group 1, P < .001). Allergy to soy was found in 23 children, of whom 87% manifested with gastrointestinal symptoms and 21 (91%) were also allergic to cow's milk. In 19 children (83%), the allergy resolved. Thirty children had allergy to sesame, and 73% of them had an atopic background. The allergy resolved in only 9 of these patients (30%) at a mean age of 2.8 years. CONCLUSIONS: The distribution of food allergens in Israel differs from that in other countries. Non-IgE-mediated food allergy and particularly milk and soy allergy were likely to resolve completely with time. Sesame allergy was 1 of the most frequent in this cohort, was usually IgE mediated, and tended to resolve in only a few patients.
Authors:
Darit Aaronov; Diana Tasher; Arie Levine; Eli Somekh; Francis Serour; Ilan Dalal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  101     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  637-40     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, E Wolfson Medical Center, Holon, Israel.
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects,  immunology
Animals
Child
Data Collection
Food Hypersensitivity / blood,  epidemiology*
Humans
Immunoglobulin E / blood
Infant
Israel / epidemiology
Medical Records
Milk / adverse effects
Questionnaires
Sesamum / adverse effects*,  immunology
Soybeans / adverse effects,  immunology
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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