| Natural history of fetal trisomy 18 after prenatal diagnosis. | |
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MedLine Citation:
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PMID: 22562870 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ObjectiveTo evaluate the natural fetal and neonatal outcome for pregnancies with an established prenatal diagnosis of fetal trisomy 18, and a parental decision for continuation of the pregnancy.MethodsThe obstetric and neonatal outcome data for 23 such pregnancies, diagnosed at a single referral Fetal Medicine Centre, were retrospectively obtained.ResultsThe overall intrauterine fetal death rate was 61%, with a progressive decline in live fetuses up to 39 weeks gestation. For fetuses diagnosed before 20 weeks gestation, there was a trend towards a higher intrauterine fetal death rate (88%), in comparison to those diagnosed after this period (44%) (p=0.06). For live births, the preterm delivery rate was 44%. All infants born alive died within 48 h of birth.ConclusionThese data provide reliable information for parental counselling pertaining to risk of intrauterine death when trisomy 18 is diagnosed prenatally. These findings suggest that long-term survival implications for trisomy 18 are different when it is diagnosed prenatally. |
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Authors:
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Annette L Burke; Katie Field; John J Morrison |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-6 |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: - ISSN: 1468-2052 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Galway University Hospital, National University of Ireland, Galway, Galway, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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