| Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis. | |
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MedLine Citation:
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PMID: 21350712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependent), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow-up, in 8 (36%) patients HCMV-DNA persisted in the intestinal specimens. Among the HCMV positive patients, 4 (50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV. Among the 14 HCMV negative patients, 3 with pouches developed pouchitis and 5 out of 11 (45%) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flare-up despite remission; it seems that the virus is not responsible for the disease relapse. |
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Authors:
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Valeria Criscuoli; Maria Rosa Rizzuto; Luigi Montalbano; Elena Gallo; Mario Cottone |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-25 Completed Date: 2011-07-18 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 633-8 Citation Subset: IM |
Affiliation:
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Dibimis, Biomedical Department of Internal and Specialist Medicine, V.Cervello Hospital Palermo, University of Palermo, Palermo 90143, Italy. vale.cic@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, Viral / blood Colitis, Ulcerative / pathology*, physiopathology*, virology* Cytomegalovirus / genetics, metabolism Cytomegalovirus Infections / pathology*, physiopathology*, prevention & control DNA, Viral / analysis Female Humans Male Middle Aged Prospective Studies Recurrence Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral; 0/DNA, Viral |
| Comments/Corrections | |
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