Document Detail

Natural history of arteriovenous malformations: analysis of non-radically treated patients.
MedLine Citation:
PMID:  18639095     Owner:  NLM     Status:  In-Data-Review    
The natural history of cerebral arteriovenous malformations (AVMs) was studied in 115 patients with untreated or incompletely obliterated AVM. Sixty-six patients had histories of hemorrhage, 20 had seizures, 18 had progressive ischemic neurologic deficits and 8 had headache. Three patients had no symptoms attributable to the AVM. Twenty-seven (23%) AVMs rebled or newly bled and the cumulative bleeding or rebleeding rate was 72.5% (4.2% per year). The cumulative bleeding rate of the neurologic deficit group, however, was significantly lower than the cumulative rebleeding rate of the hemorrhagic group (P < 0.05) and that of the seizure group (P < 0.05). No significant differences were found in regard to the initial clinical manifestations. The cumulative survival rate was 84% and the average mortality rate was 1.4% per year. Fifty patients (43%) were below 90 in Karnofsky's Index at the end of the follow-up period and the average morbidity rate was 6.0% per year.
F Yamane; M Takeshita; M Izawa; M Kagawa; K Sato; K Takakura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  5 Suppl     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  1998 Mar 
Date Detail:
Created Date:  2008-07-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  26-9     Citation Subset:  -    
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College, Tokyo, Japan.
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