| Natural history of Rett syndrome. | |
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MedLine Citation:
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PMID: 16225833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rett syndrome is a unique neurodevelopmental disorder, with onset of hypotonia, autistic tendency, and abnormalities of fine finger movements and gross movements of the arms in early infancy. Clinical features include specific age-dependent symptoms. Studies of early and late signs correlated locomotive dysfunction to language disability and stereotypy to regression of higher cortical functions. Studies of sleep parameters revealed early hypofunction of brainstem aminergic neurons and late occurrence of hypofunction of dopaminergic neurons, followed by receptor supersensitivity. The syndrome's pathophysiology suggests that early hypofunction of aminergic neurons interferes with the development of higher neuronal systems. Particular symptoms surface at different ages throughout the natural course of Rett syndrome, with regressional and static periods. |
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Authors:
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Yoshiko Nomura; Masaya Segawa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of child neurology Volume: 20 ISSN: 0883-0738 ISO Abbreviation: J. Child Neurol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-10-17 Completed Date: 2005-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: Canada |
Other Details:
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Languages: eng Pagination: 764-8 Citation Subset: IM |
Affiliation:
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Segawa Clinic for Children, Tokyo, Japan. nomura-y@segawa-clinic.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Humans Rett Syndrome / classification, etiology*, physiopathology* Sleep / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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