Document Detail

Natural cycle in-vitro fertilization with embryo cryopreservation prior to chemotherapy for carcinoma of the breast.
MedLine Citation:
PMID:  8671185     Owner:  NLM     Status:  MEDLINE    
Chemotherapeutic treatment for malignant disease may cause infertility secondary to gonadal failure. In-vitro fertilization (IVF) with embryo cryopreservation prior to chemotherapy has been described as a means of preserving future fertility potential. However, the supraphysiological levels of sex steroids that result from ovarian stimulation for IVF may, at least theoretically, stimulate growth of malignant cells in a patient with a hormonally sensitive tumour such as carcinoma of the breast. This report describes a patient with carcinoma of the breast who underwent IVF in the natural cycle prior to embarking on a course of combination chemotherapy. Of three oocytes retrieved, two fertilized and were cryopreserved. This case represents a novel application of IVF with embryo cryopreservation in the natural cycle. Although embryo thawing and transfer have not yet been attempted, the patient has already benefitted psychologically from having the opportunity to assume an element of control over her reproductive future. Should pregnancy occur, this would be the first report of human pregnancy from cryopreserved embryos obtained in a natural cycle.
J R Brown; E Modell; M Obasaju; Y K King
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  11     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  197-9     Citation Subset:  IM    
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY, USA.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects,  therapeutic use
Breast Neoplasms / drug therapy*,  radiotherapy,  surgery
Embryo, Mammalian*
Fertilization in Vitro*
Infertility, Female / chemically induced
Menstrual Cycle

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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