Document Detail

Natural cycle cryo-thaw transfer may improve pregnancy outcome.
MedLine Citation:
PMID:  17450431     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare natural vs. hormone replacement treatment (HRT) for cryo-thaw embryo transfer cycles in patients with frozen embryos from previous ART.
DESIGN AND SETTINGS: Retrospective chart review of 164 patients (242 cycles) who underwent natural or HRT cryo-thaw embryo transfer between January 2002 and April 2005.
MAIN OUTCOME MEASURES: Pregnancy rates per transfer in natural and HRT cryo-thaw cycles.
RESULTS: The pregnancy rate per transfer was higher with natural cycles (36.76% vs. 22.99%, P = 0.0298). There was no statistical difference in mean age, endometrial thickness, and average embryo quality in successful cycles. Mean endometrial thickness prior to transfer was greater in natural cycles (9.95 vs. 8.89 mm, P < 0.001). Mean serum estradiol levels were higher in the HRT group prior to transfer (526.1 vs. 103.8 pg/ml, P < 0.001), and were found to be lower in women who achieved pregnancy (337.1 vs. 433.3 pg/ml, P = 0.0136).
CONCLUSION: Hormone replacement in preparation for cryo-thaw transfer of embryos was found to be associated with decreased pregnancy rates in comparison to natural cycle cryo-thaw transfer. Greater endometrial thickness was achieved with lower serum estradiol levels in patients undergoing natural cycles, suggesting that higher estradiol levels during HRT cycle may interfere with the window of implantation.
Vadim Morozov; Jane Ruman; Daniel Kenigsberg; Glenn Moodie; Steven Brenner
Publication Detail:
Type:  Journal Article     Date:  2007-02-16
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  24     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-23     Completed Date:  2007-09-12     Revised Date:  2013-03-27    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-23     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Long Island Jewish Medical Center, Long Island Campus of Albert Einstein College of Medicine of Yeshiva University, New Hyde Park, NY 11040, USA.
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MeSH Terms
Embryo Transfer*
Estrogen Replacement Therapy*
Menstrual Cycle
Pregnancy Outcome*
Reproductive Techniques, Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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