| Natural cycle IVF with and without terminal HCG: learning from failed cycles. | |
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MedLine Citation:
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PMID: 17697489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural cycle IVF, without the use of LH down-regulation, is difficult because women start spontaneous LH surges at any time of the day and on any day of the week. This is not readily compatible with delivery of a routine IVF service and so historically the natural cycle has been modified by the use of human chorionic gonadotrophin (HCG) to make the natural cycle fit convenient clinical practice. This report re-evaluates data collected some years ago and seeks to determine whether the use of HCG is ultimately beneficial. Two large series of natural cycle IVF where only LH monitoring was performed (534 cycles) or where this was combined with HCG as necessary (241 cycles) were analysed. In essence, the use of HCG introduced as many problems as it overcame: there was no net benefit with respect to the number of eggs collected or clinical pregnancies generated. In fact there was an overall deterioration in all indices. The principle difficulties with natural cycle IVF are those associated with the prediction of follicle maturity and hence timing egg collection, and the conflict between costly and intrusively frequent monitoring with simpler but far less effective approaches. |
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Authors:
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Elizabeth A Lenton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 15 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Affiliation:
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Greencroft House, Moorwood Lane, Sheffield, S17 3BS, UK. ivf@lento.plus.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Appointments and Schedules* Chorionic Gonadotropin / administration & dosage* Cyclooxygenase Inhibitors / pharmacology Embryo Transfer Female Fertilization in Vitro / methods* Humans Indomethacin / pharmacology Infertility, Female / drug therapy* Menstrual Cycle / drug effects* Middle Aged Ovulation / drug effects Pregnancy Pregnancy Rate Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Cyclooxygenase Inhibitors; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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