Document Detail

Natural cycle IVF in unexplained, endometriosis-associated and tubal factor infertility.
MedLine Citation:
PMID:  11726579     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To elucidate possible differences between unexplained and minimal peritoneal endometriosis-associated infertility, we studied their outcome in natural cycle IVF (NIVF). METHODS: A prospective cohort study was carried out on unexplained (33 couples), minimal peritoneal endometriosis-associated (30 couples) and tubal factor (24 couples) infertility in 223 NIVF cycles, using human chorionic gonadotrophin (HCG) for ovulation induction. RESULTS: During the first NIVF attempt, follicular and luteal phase oestradiol, FSH, LH and progesterone concentrations, as well as endometrial thickness and follicular diameter were similar among the three groups. Periovulatory follicular growth monitored from day of HCG administration to oocyte aspiration was significantly lowered in unexplained infertility compared with minimal endometriosis-associated and tubal factor infertility. The fertilization rate, clinical pregnancy rate per initiated cycle, per successful oocyte retrieval and per embryo transfer, in minimal endometriosis (80.0, 10.4, 16.0 and 23.5% respectively) were similar to that in tubal factor infertility patients (68.6, 5.8, 11.4 and 16.0%) but significantly higher (P < 0.05) than that of the unexplained infertility group (62.2, 2.6, 5.4 and 8.7%). CONCLUSIONS: The significant reduction in follicular periovulatory growth, fertilization and pregnancy rates in unexplained infertility compared with minimal peritoneal endometriosis patients may be explained by sub-optimal follicular development with possibly reduced oocyte quality, intrinsic embryo quality factors or by impaired implantation. From a clinical point of view, NIVF is less suited to unexplained infertility treatment, but might represent an interesting treatment option for minimal peritoneal endometriosis-associated infertility.
A K Omland; P Fedorcsák; R Storeng; P O Dale; T Abyholm; T Tanbo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  16     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-29     Completed Date:  2002-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2587-92     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, National Hospital, University of Oslo, Oslo, Norway.
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MeSH Terms
Cohort Studies
Endometriosis / complications*,  pathology
Endometrium / pathology
Estradiol / blood
Fallopian Tube Diseases / complications*,  pathology
Fertilization in Vitro / methods*
Follicle Stimulating Hormone / blood
Follicular Phase
Infertility / therapy*
Infertility, Female / etiology*,  pathology,  therapy*
Luteal Phase
Luteinizing Hormone / blood
Ovarian Follicle / pathology
Progesterone / blood
Prospective Studies
Treatment Outcome
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone
Comment In:
Hum Reprod. 2002 Jul;17(7):1926-7; author reply 1927   [PMID:  12093863 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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