| Natural course of untreated microalbuminuria in children and adolescents with type 1 diabetes and the importance of diabetes duration and immigrant status: longitudinal analysis from the prospective nationwide German and Austrian diabetes survey DPV. | |
| | |
MedLine Citation:
|
PMID: 22199141 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective: Aim was to identify risk factors for the development and progression of untreated persistent microalbuminuria in children and adolescents with type 1 diabetes.Design and Methods: A total number of 683 children and adolescents with type 1 diabetes recruited from the prospective nationwide German and Austrian diabetes survey (DPV) were included in the analysis. Inclusion criteria were onset of type 1 diabetes under the age of 11 years, diabetes duration of more than one year and continuous follow-up over five years with at least two documented urine analyses per year. Subjects treated with angiotensin converting enzyme inhibitors were excluded. Risk factors gender, BMI SDS, diabetes duration, HbA1c, cholesterol, HDL, LDL, systolic and diastolic blood pressure, and immigrant status were analysed by logistic regression.Results: At baseline (age 10.5+/-0.1 years, diabetes duration 4.6+/-2.4 years, HbA1c 7.4+/-1.1%) 75.6% of children had normoalbuminuria, 15.7% had intermittent microalbuminuria, 8.6% of subjects had persistent microalbuminuria, and 0.1% had macroalbuminuria. After a follow-up-time of five years, 59.4% of adolescents continued to have normoalbuminuria, 18.4% had progression, 15.2% had regression of microalbuminuria, and in 6.9% of subjects microalbuminuria remained unchanged. We found significant associations between persistent microalbuminuria at baseline and during each year of follow-up (p<0.0001). Logistic regression analysis identified diabetes duration and immigrant status as significant factors for microalbuminuria (p=0.009 and p=0.009).Conclusions: The survey in a real world setting shows that diabetes duration and immigrant status are risk factors for the development and progression of untreated microalbuminuria in children and adolescents with type 1 diabetes. |
| | |
Authors:
|
Angela Galler; Holger Haberland; Andrea Näke; Sabine Elisabeth Hofer; Martin Holder; Klemens Raile; Reinhard Holl |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
A Galler, Paediatric Endocrinology and Diabetology, Charité - Universitätsmedizin Berlin, Berlin, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of Transplacental Treatment for Fetal Congenital Bradyarrhythmia.
Next Document: Emergency department crowding: prioritising quantified crowding measures using a Delphi study.