Document Detail

Natural course of the functional and morphological changes in canine autogenous arterial graft.
MedLine Citation:
PMID:  11340268     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We examined the time course of endothelium-dependent and -independent responses in reversed autogenous arterial grafts during regeneration and tissue repair processes after arterial grafting in dogs. MATERIALS AND METHODS: Autogenous arterial grafts implanted in the canine femoral artery were removed, cut into rings and suspended in organ chambers for isometric tension recording on the 1st, 3rd, 7th, 14th and 28th days after implantation. Electron-microscopic examination on the 1st, 3rd,7th, 14th and 28th days after transplantation was also performed. Control arteries were taken from nonsurgically treated femoral arteries. RESULTS: Acetylcholine (ACh) and A23187 caused endothelium-dependent relaxations in arterial grafts throughout the study. Although endothelium-dependent relaxations to ACh and A23187 on the 3rd day after transplantation were only significantly impaired compared to those of control, they were similar to the control within 1 week after grafting. Smooth muscle relaxations in response to sodium nitroprusside in arterial grafts throughout the study were comparable with those of control arteries. No apparent intimal thickening of the arterial grafts was observed. Electron microscopy scanning revealed mild endothelial cell damage in implanted autogenous arterial grafts on the 1st or 3rd day after grafting. Seven to 14 days after grafting, the endothelial cell layer appeared to be normal. CONCLUSIONS: It was observed that the endothelial function remained intact and there was an absence of intimal thickening in the arterial grafts. These observations may explain the improved patency of autogenous arterial grafts compared to the vein grafts in aortocoronary revascularization.
C G Wei; K Komori; E Mori; M Kume; T Yamaoka; T Matsumoto; K Sugimachi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  33     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-07     Completed Date:  2001-07-05     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Arteries / pathology,  transplantation*
Femoral Artery / surgery*
Microscopy, Electron
Muscle, Smooth, Vascular / drug effects,  physiopathology
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Transplantation, Autologous
Vasoconstrictor Agents / pharmacology
Reg. No./Substance:
0/Vasoconstrictor Agents; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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