| Natural killer/T-cell lymphoma of nasal type with intraocular involvement: case report. | |
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MedLine Citation:
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PMID: 19882515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report an unusual presentation of disseminated, intraocular, extranodal natural killer/T-cell lymphoma, nasal type (NK/T-cell lymphoma), originating from nasal NK/T-cell lymphoma. METHODS: Case report. RESULTS: A 63-year-old woman who had been treated with systemic chemotherapy and radiotherapy for NK/T-cell lymphoma in the nasal cavity presented with vitreous haze of the right eye. Despite anti-inflammatory therapy, the right eye showed poor clinical response and received diagnostic vitrectomy. The vitreous opacity resembled a thin sheet, with no sign of subretinal infiltrate or vascular sheathing. The vitreous specimen contained many large, pleomorphic lymphoma cells. The malignant cells were positive for CD3, CD8, and granzyme B. Systemic workups showed no involvement of other organs. A diagnosis of T-cell lymphoma in the vitreous was made; the tumor likely originated from nasal NK/T-cell lymphoma. The patient was treated with intrathecal chemotherapy and intravitreal methotrexate injection. The eye was clinically clear of malignant cells after the injections. CONCLUSIONS: Vitreous infiltration without uveoretinal involvement can be an unusual manifestation of intraocular NK/T-cell lymphoma. Clinician awareness of possible ocular involvement may assist in the diagnosis of disseminated NK/T-cell lymphoma. |
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Authors:
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Eun Ji Lee; Tae Wan Kim; Jang Won Heo; Hyeong Gon Yu; Hum Chung |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of ophthalmology Volume: 20 ISSN: 1120-6721 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-01-04 Completed Date: 2010-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 215-7 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use Eye Neoplasms / drug therapy, pathology* Female Humans Injections, Spinal Killer Cells, Natural* Lymphoma, T-Cell / drug therapy, pathology* Middle Aged Neoplasm Invasiveness Nose Neoplasms / drug therapy, pathology* Vitrectomy Vitreous Body / pathology* |
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