Document Detail

Natural alternatives to in-feed antibiotics in pig production: can immunomodulators play a role?
MedLine Citation:
PMID:  22443549     Owner:  NLM     Status:  In-Data-Review    
As a result of the European ban of in-feed growth-promoting antibiotics, new strategies are being developed to increase the resistance to disease in farm animals. In pig production, this is of particular importance during the weaning transition when piglets are subjected to major stressful events, making them highly sensitive to digestive disorders. At this time, the development of both innate and adaptive immunity at the mucosal surface is critical in preventing the potential harmful effects of intestinal pathogenic agents. Strategies aiming at stimulating natural host defences through the use of substances able to modulate immune functions have gained increasing interest in animal research, and different bioactive components a priori sharing those properties have been the subject of in vivo nutritional investigations in pig. Among these, yeast derivates (β-glucans and mannans) are able to interact with immune cells, particularly phagocytic cells. However, studies where they have been fed to pigs have shown inconsistent results, suggesting that their ability to target the sensitive immune cells through the oral route is questionable. The plant extracts, which would benefit from a positive image in the public opinion, have also been tested. However, due to a lack of data on the bioactive components of particular plants and the large diversity of species, it has proved difficult to prepare extracts of equivalent potency and thus, the literature on their influence on pig immunity remains inconclusive. In considering piglet immunity and health benefits, the most promising results to date have been obtained with spray-dried animal plasma, whose positive effects would be provided by specific antibodies and non-specific competition of some plasma components with bacteria for intestinal receptors. The major positive effect of spray-dried animal plasma is in reducing the infiltration of gut-associated lymphoid tissue by immune cells, which is likely to be the result of a decreased colonisation by potentially harmful bacteria. This review also highlights the limitations of some of the published in vivo studies on the immunomodulatory activity of certain feed additives. Among those, the lack of standardisation of extracts and the heterogeneity of piglet-rearing conditions (e.g. exposure to pathogens) are likely the most limiting.
M Gallois; H J Rothkötter; M Bailey; C R Stokes; I P Oswald
Related Documents :
22606989 - Dual role of autophagy in hiv-1 replication and pathogenesis.
2642769 - Immunoregulation in clinical diseases: an overview.
22447659 - Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis.
22289049 - Melatonin enhances thapsigargin-induced apoptosis through reactive oxygen species-media...
22800509 - Lipocalin 2, a new gadd153 target gene, as an apoptosis inducer of endoplasmic reticulu...
17198749 - Protein hormones and immunity.
21524159 - Modulation of the dendritic cell-t-cell synapse to promote pathogen immunity and preven...
23661289 - Artemisinin induces a549 cell apoptosis dominantly via a reactive oxygen species-mediat...
22995069 - Riccardin d-26, a synthesized macrocyclic bisbibenzyl compound, inhibits human hepatoce...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Animal : an international journal of animal bioscience     Volume:  3     ISSN:  1751-7311     ISO Abbreviation:  Animal     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2012-03-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101303270     Medline TA:  Animal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1644-61     Citation Subset:  -    
1INRA, UR66, Laboratoire de Pharmacologie-Toxicologie, Centre de Recherche de Toulouse, BP3 31931, Toulouse cedex 9, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impact of bioactive substances on the gastrointestinal tract and performance of weaned piglets: a re...
Next Document:  Effects of inbreeding and other genetic components on equine fertility.