| Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression. | |
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MedLine Citation:
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PMID: 17917056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The natural CD4+CD25+ T regulatory (Treg) lymphocyte has emerged as a critical cell for controlling immune responses to self, foreign proteins, and pathogens. Identified initially by the constitutive expression of CD4 and CD25, natural Tregs suppress a variety of immune cells and responses, including CD4+CD25- proliferation and IL-2 production, and CD8 cell proliferation, IFNgamma production and CTL activity. Although natural Tregs require activation with specific antigen to attain their suppressive phenotype, once activated they execute inhibition in an antigen specific as well as non-specific (bystander) fashion. Treg suppression depends on IL-2, CD25, and cell:cell contact. The use of live cell imaging in vivo and in vitro to visualize the dynamic cell:cell interactions involving natural Tregs as well as the CD4+CD25+ Treg inhibitory hybridoma RD6 has refined the mechanistic models of contact dependent Treg suppression. |
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Authors:
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Elizabeth H Field; Katarina Kulhankova; Mohamed E Nasr |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunologic research Volume: 39 ISSN: 0257-277X ISO Abbreviation: Immunol. Res. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-10-05 Completed Date: 2008-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 62-78 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Rheumatology, Roy J and Lucille A Carver College of Medicine, Iowa City, IA, USA. liz-field@icva.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD4 / analysis Autoimmunity Cell Communication Graft Rejection Humans Hybridomas / immunology Immune Tolerance* Interleukin-2 / immunology, metabolism Interleukin-2 Receptor alpha Subunit / analysis Receptors, Antigen, T-Cell / immunology Receptors, Interleukin-2 / immunology, metabolism* T-Lymphocyte Subsets / immunology T-Lymphocytes, Regulatory / cytology, immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4; 0/Interleukin-2; 0/Interleukin-2 Receptor alpha Subunit; 0/Receptors, Antigen, T-Cell; 0/Receptors, Interleukin-2 |
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