| Natural Products as Sources of New Fungicides (I): Synthesis and antifungal activity of acetophenone derivatives against phytopathogenic fungi. | |
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MedLine Citation:
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PMID: 23036111 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Several series of forty-five acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by (1) H and (13) C NMR spectroscopy, HRMS and single crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate assay. Of them 12 derivatives (e.g., 3a-c, 4c and 4e) exhibited more potent antifungal effects on some phytopathogens than a commercial fungicide hymexazol as positive control. In particular, compound 3b with IC(50) values of 10 to 19 μg /mL was found to be the most active in this series and might be a potential lead structure for further optimization. The preliminary structure-activity relationship (SAR) studies of a series of acetophenones are also discussed. © 2012 John Wiley & Sons A/S. |
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Authors:
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Ya-Tuan Ma; Hua-Fang Fan; Yu-Qi Gao; He Li; An-Ling Zhang; Jin-Ming Gao |
Publication Detail:
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Type: LETTER Date: 2012-10-4 |
Journal Detail:
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Title: Chemical biology & drug design Volume: - ISSN: 1747-0285 ISO Abbreviation: Chem Biol Drug Des Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262549 Medline TA: Chem Biol Drug Des Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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