Document Detail

Natural Products as Sources of New Fungicides (I): Synthesis and antifungal activity of acetophenone derivatives against phytopathogenic fungi.
MedLine Citation:
PMID:  23036111     Owner:  NLM     Status:  Publisher    
Several series of forty-five acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by (1) H and (13) C NMR spectroscopy, HRMS and single crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate assay. Of them 12 derivatives (e.g., 3a-c, 4c and 4e) exhibited more potent antifungal effects on some phytopathogens than a commercial fungicide hymexazol as positive control. In particular, compound 3b with IC(50) values of 10 to 19 μg /mL was found to be the most active in this series and might be a potential lead structure for further optimization. The preliminary structure-activity relationship (SAR) studies of a series of acetophenones are also discussed. © 2012 John Wiley & Sons A/S.
Ya-Tuan Ma; Hua-Fang Fan; Yu-Qi Gao; He Li; An-Ling Zhang; Jin-Ming Gao
Publication Detail:
Type:  LETTER     Date:  2012-10-4
Journal Detail:
Title:  Chemical biology & drug design     Volume:  -     ISSN:  1747-0285     ISO Abbreviation:  Chem Biol Drug Des     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262549     Medline TA:  Chem Biol Drug Des     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China.
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