| Natural products for type II diabetes treatment. | |
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MedLine Citation:
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PMID: 20378050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural products such as plant extracts and complex microbial secondary metabolites have recently attracted the attention of scientific world for their potential use as drugs for treating chronic diseases such as Type II diabetes. Non-Insulin-Dependent Diabetes Mellitus (NIDDM) or Type II diabetes has complicated basis and has various treatment options, each targeting different mechanism of action. One such option relies on digestive enzyme inhibition. Almost all of the currently used clinically digestive enzyme inhibitors are bacterial secondary metabolites. However in most cases understanding of their complete biosynthetic pathways remains a challenge. The currently used digestive enzyme inhibitors have significant side effects that have restricted their usage. Hence, many active plant metabolites are being investigated as more effective treatment with fewer side effects. Flavonoids, terpenoids, glycosides are few to name in that class. Many of these are proven inhibitors of digestive enzymes but their large scale production remains a technical conundrum. Their successful heterologous production in simple host bacteria in scalable quantities gives a new dimension to the continuously active research for better treatment for type II diabetes. Looking at existing and new methods of mass level production of digestive inhibitors and latest efforts to effectively discover new potential drugs is the subject of this book chapter. |
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Authors:
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Amruta Bedekar; Karan Shah; Mattheos Koffas |
Publication Detail:
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Type: Journal Article; Review Date: 2010-02-20 |
Journal Detail:
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Title: Advances in applied microbiology Volume: 71 ISSN: 0065-2164 ISO Abbreviation: Adv. Appl. Microbiol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-09 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370413 Medline TA: Adv Appl Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 21-73 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Chemical and Biological Engineering, University of Buffalo, SUNY, Buffalo, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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metabolism* Biological Products / metabolism, therapeutic use* Diabetes Mellitus, Type 2 / therapy* Enzyme Inhibitors / metabolism, therapeutic use* Humans Hypoglycemic Agents / therapeutic use* Middle Aged Phytotherapy Pinus Plant Bark / chemistry Plant Extracts / therapeutic use* Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Biological Products; 0/Enzyme Inhibitors; 0/Hypoglycemic Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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