| Natural Killer Cells in HIV-1 Infection: A Double-Edged Sword. | |
| | |
MedLine Citation:
|
PMID: 21587340 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
In order to propagate and persist within the host, HIV-1 subverts a variety of checkpoints of innate and adaptive viral immunosurveillance. Many of these are related to natural killer cells, which bridge innate and adaptive immunity and play a major role in defeating virus infections. HIV-1 affects cytotoxicity of natural killer cells towards infected cells and natural killer cell-mediated priming of effector cells of the adaptive immune system. Moreover, a subpopulation of natural killer cells was found sensitive to infection by HIV-1. Consequently, an efficient immune response against HIV-1 cannot be mounted in most patients. The current review highlights the molecular interplay between HIV-1 and effector cells of the host immune system with a focus on natural killer cells, and summarizes strategies of HIV-1 to escape from natural killer cell immunosurveillance. A detailed knowledge of these immune escape strategies might lead to the identification of access points for intervention in order to block infection and progression to AIDS. |
| | |
Authors:
|
Jessica Funke; Ralf Dürr; Ursula Dietrich; Joachim Koch |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: AIDS reviews Volume: 13 ISSN: 1698-6997 ISO Abbreviation: AIDS Rev Publication Date: 2011 Apr-Jun |
Date Detail:
|
Created Date: 2011-05-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101134876 Medline TA: AIDS Rev Country: Spain |
Other Details:
|
Languages: eng Pagination: 67-76 Citation Subset: IM |
Affiliation:
|
Georg-Speyer-Haus, Institute of Biomedical Research, Frankfurt am Main, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Search for a Cure for Persistent HIV Reservoirs.
Next Document: European Recommendations for the Clinical Use of HIV Drug Resistance Testing: 2011 Update.