| Natural killer cell lymphoma in a pediatric patient with inflammatory bowel disease. | |
| | |
MedLine Citation:
|
PMID: 20837584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tumor necrosis factor α (TNF-α) antibody agents are an effective therapy for the treatment of inflammatory bowel disease (IBD); however, because of the potential for immune suppression with these drugs, TNF-α antibody agents can increase the risk of malignancy. We report here the case of an 11-year-old boy who presented with bowel obstruction. He also had a history of periodic fever, aphthous stomatitis, and cervical adenitis (PFAPA). Intestinal inflammation continued and impaired his quality of life; he was diagnosed with IBD of an undetermined type (IBD-U). Symptoms improved with infliximab, but he developed elevated transaminase levels with hepatosplenomegaly 1 year after scheduled infusions. Skin biopsy revealed an atypical lymphoid infiltrate consistent with an Epstein-Barr virus (EBV)-positive natural killer (NK)/T-cell lymphoma with associated hemophagocytic lymphohistiocytosis. Bone marrow biopsy revealed a similar EBV-positive lymphoid infiltrate consistent with an NK/T-cell lymphoma. EBV-positive tissue was present in gastrointestinal biopsies. Flow-cytometric analysis revealed an atypical, clonal NK-cell population, and biopsy specimens from several tissue sites tested positive for CD3, CD56, and CD30. The patient died soon after the diagnosis was made. This patient developed an EBV-driven malignancy while receiving infliximab. All patients with IBD who receive infliximab should be monitored for malignancy, especially young patients. This case underscores the need for future studies to better understand the biology of lymphoproliferative disorders. |
| | |
Authors:
|
Mark Deneau; Jeremy Wallentine; Stephen Guthery; Molly O'Gorman; John Bohnsack; Mark Fluchel; John Bezzant; John F Pohl |
Related Documents
:
|
21064094 - Inhibition of mammalian target of rapamycin signaling by everolimus induces senescence ... 21883264 - Flow cytometry assessment of apoptotic cd34+ cells by annexin v labeling may improve pr... 8622884 - Expression of cell-cycle regulatory genes in htlv-i infected t-cell lines: possible inv... 9445014 - Inhibition of p53 transactivation function by the human t-cell lymphotropic virus type ... 7708954 - Basal cell density in human skin for various fractionation schedules in radiotherapy. 6432794 - Modification of glutathione levels in c3h/10t1/2 cells and its relationship to benzo(a)... |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2010-09-13 |
Journal Detail:
|
Title: Pediatrics Volume: 126 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-05 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: e977-81 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatric Gastroenterology, Primary Children's Hospital, University of Utah, 100 N Mario Capecchi Dr, Suite 2650, Salt Lake City, UT 84113-1103, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibodies, Monoclonal
/
adverse effects,
therapeutic use Child Gastrointestinal Agents / adverse effects, therapeutic use Humans Inflammatory Bowel Diseases / complications*, drug therapy* Lymphoma, Extranodal NK-T-Cell / complications*, diagnosis Male Tumor Necrosis Factor-alpha / immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/Tumor Necrosis Factor-alpha; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pediatric Clinical Research Networks: Current Status, Common Challenges, and Potential Solutions.
Next Document: Helmet Versus Active Repositioning for Plagiocephaly: A Three-Dimensional Analysis.