| Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment. | |
| | |
MedLine Citation:
|
PMID: 21412692 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Obesity is a multifactorial disease characterized by an excessive weight for height due to an enlarged fat deposition such as adipose tissue, which is attributed to a higher calorie intake than the energy expenditure. The key strategy to combat obesity is to prevent chronic positive impairments in the energy equation. However, it is often difficult to maintain energy balance, because many available foods are high-energy yielding, which is usually accompanied by low levels of physical activity. The pharmaceutical industry has invested many efforts in producing antiobesity drugs; but only a lipid digestion inhibitor obtained from an actinobacterium is currently approved and authorized in Europe for obesity treatment. This compound inhibits the activity of pancreatic lipase, which is one of the enzymes involved in fat digestion. In a similar way, hundreds of extracts are currently being isolated from plants, fungi, algae, or bacteria and screened for their potential inhibition of pancreatic lipase activity. Among them, extracts isolated from common foodstuffs such as tea, soybean, ginseng, yerba mate, peanut, apple, or grapevine have been reported. Some of them are polyphenols and saponins with an inhibitory effect on pancreatic lipase activity, which could be applied in the management of the obesity epidemic. |
| | |
Authors:
|
Ana Laura de la Garza; Fermín I Milagro; Noemí Boque; Javier Campión; J Alfredo Martínez |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-16 |
Journal Detail:
|
Title: Planta medica Volume: - ISSN: 1439-0221 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0066751 Medline TA: Planta Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Towards the Synthesis of Proanthocyanidins: Half a Century of Innovation.
Next Document: hERG Channel Inhibitors in Extracts of Coptidis Rhizoma.