| Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential. | |
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MedLine Citation:
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PMID: 22262757 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Natural IgM Abs are the constitutively secreted products of B1 cells (CD5(+) in mice and CD20(+)CD27(+)CD43(+)CD70(-) in humans) that have important and diverse roles in health and disease. Whereas the role of natural IgM as the first line of defense for protection against invading microbes has been extensively investigated, more recent reports have highlighted their potential roles in the maintenance of tissue homeostasis via clearance of apoptotic and altered cells through complement-dependent mechanisms, inhibition of inflammation, removal of misfolded proteins, and regulation of pathogenic autoreactive IgG Abs and autoantibody-producing B cells. These observations have provided the theoretical underpinnings for efforts that currently seek to harness the untapped therapeutic potential of natural IgM either by boosting in vivo natural IgM production or via therapeutic infusions of monoclonal and polyclonal IgM preparations. |
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Authors:
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Srini V Kaveri; Gregg J Silverman; Jagadeesh Bayry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 188 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 939-45 Citation Subset: AIM; IM |
Affiliation:
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INSERM Unité 872, Paris, F-75006, France; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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