| Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound study. | |
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MedLine Citation:
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PMID: 20439786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The natural history of heterogeneous atherosclerotic plaques and the role of local hemodynamic factors throughout their development are unknown. We performed a serial study to assess the role of endothelial shear stress (ESS) and vascular remodeling in the natural history of coronary atherosclerosis. METHODS AND RESULTS: Intravascular ultrasound-based 3-dimensional reconstruction of all major coronary arteries (n=15) was performed serially in vivo in 5 swine 4, 11, 16, 23, and 36 weeks after induction of diabetes mellitus and hyperlipidemia. The reconstructed arteries were divided into 3-mm-long segments (n=304). ESS was calculated in all segments at all time points through the use of computational fluid dynamics. Vascular remodeling was assessed at each time point in all segments containing significant plaque, defined as maximal intima-media thickness >/=0.5 mm, at week 36 (n=220). Plaque started to develop at week 11 and progressively advanced toward heterogeneous, multifocal lesions at all subsequent time points. Low ESS promoted the initiation and subsequent progression of plaques. The local remodeling response changed substantially over time and determined future plaque evolution. Excessive expansive remodeling developed in regions of very low ESS, further exacerbated the low ESS, and was associated with the most marked plaque progression. The combined assessment of ESS, remodeling, and plaque severity enabled the early identification of plaques that evolved to high-risk lesions at week 36. CONCLUSIONS: The synergistic effect of local ESS and the remodeling response to plaque formation determine the natural history of individual lesions. Combined in vivo assessment of ESS and remodeling may predict the focal formation of high-risk coronary plaque. |
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Authors:
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Konstantinos C Koskinas; Charles L Feldman; Yiannis S Chatzizisis; Ahmet U Coskun; Michael Jonas; Charles Maynard; Aaron B Baker; Michail I Papafaklis; Elazer R Edelman; Peter H Stone |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-03 |
Journal Detail:
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Title: Circulation Volume: 121 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-18 Completed Date: 2010-06-07 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2092-101 Citation Subset: AIM; IM |
Affiliation:
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Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Artery Disease / epidemiology, physiopathology*, ultrasonography* Coronary Circulation / physiology* Diabetes Mellitus, Experimental / epidemiology, physiopathology Diabetic Angiopathies / epidemiology, physiopathology, ultrasonography Disease Models, Animal Endothelium, Vascular / physiology* Male Predictive Value of Tests Risk Factors Stress, Mechanical Swine Ultrasonography, Interventional Ventricular Remodeling / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM 49039/GM/NIGMS NIH HHS; R01 GM049039-15/GM/NIGMS NIH HHS; R01 GM049039-16/GM/NIGMS NIH HHS |
| Comments/Corrections | |
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