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Natural Flavone Kaempferol Suppresses Chemokines Expression in Human Monocyte THP-1 Cells through MAPK Pathways.
MedLine Citation:
PMID:  21535503     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  There is increasing evidence that daily intake of flavonoids reduced severity and prevalence of allergic diseases. However, the mechanism of its antiinflammatory effects in allergic diseases remains uncertain. Kaempferol, which belongs to the flavone group, is a strong antioxidant among natural flavonoids and is the essential component of many beverages and vegetables. Because chemokine is one of the key mediators in allergic inflammatory process, we investigated the effect of kaempferol on chemokines expression in monocytes. Our data demonstrated that kaempferol significantly inhibited the lipopolysaccharide (LPS)-induced production of monocyte-derived chemokine (MDC), interferon gamma-induced protein 10 (IP-10), and interleukin-8 (IL-8) in THP-1 cells. Growth-related oncogene-α (GRO-α) was also suppressed at a higher concentration. We also found that kaempferol was able to suppress LPS-induced mitogen-activated protein kinase (MAPK) pathways, as well as the phosphorylation of upstream c-raf and MEK1/2. In brief, kaempferol suppressed LPS-induced T helper 1 (Th1), T helper 2 (Th2), and neutrophil-related chemokines production in monocytes might be via the MAPK pathways.
Authors:
Ching-Hua Huang; Ren-Long Jan; Chang-Hung Kuo; Yu-Te Chu; Wei-Li Wang; Min-Sheng Lee; Huan-Nan Chen; Chih-Hsing Hung
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of food science     Volume:  75     ISSN:  1750-3841     ISO Abbreviation:  -     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2011-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  H254-H259     Citation Subset:  -    
Affiliation:
Author Huang is with Dept. of Pediatrics, Yuan's General Hospital. Author Jan is with Dept. of Pediatrics, Chi Mei Medical Center, Liouying. Authors Kuo, Wang, and Hung are with Dept. of Pediatrics, Kaohsiung Municipal Ta-Tung Hospital. Authors Chu, Lee, and Hung are with Dept. of Pediatrics, Faculty of Pediatrics, College of Medicine, Kaohsiung Medical Univ. Authors Kuo, Chu, Wang, Lee, Chen, and Hung are with Dept. of Pediatrics, Kaohsiung Medical Univ. Hospital. Authors Kuo and Hung are with Graduate Inst. of Medicine, Kaohsiung Medical Univ., Taiwan. Direct inquiries to author Hung (E-mail: pedhung@gmail.com).
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