| Natural course of adult-onset foveomacular vitelliform dystrophy: a spectral-domain optical coherence tomography analysis. | |
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MedLine Citation:
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PMID: 21664595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe the natural course of adult-onset foveomacular vitelliform dystrophy using spectral-domain optical coherence tomography (SD-OCT). DESIGN: Retrospective study. METHODS: We reviewed the charts of all consecutive patients with adult-onset foveomacular vitelliform dystrophy who underwent SD-OCT at baseline and at least 12 months later (last visit). Main outcome measures were changes of clinical and SD-OCT features over time. RESULTS: Forty-six eyes (31 patients, 15 male and 16 female; mean age 74.6 ± 8.2 years) were included. Follow-up was 16.2 ± 6 (range, 12-30) months. Visual acuity (VA) reduced from 0.32 ± 0.22 logMAR at baseline to 0.39 ± 0.28 logMAR at last visit (P=.03). The stage of the disease was vitelliform in 28 eyes (60.8%), pseudohypopyon in 7 eyes (15.2%), vitelliruptive in 11 eyes (23.9%) at baseline; vitelliform in 23 eyes (50%), pseudohypopyon in 5 eyes (10.9%), vitelliruptive in 13 eyes (28.2%), and atrophic in 5 eyes (10.9%) at last visit. Stabilization of the disease stage, inner segment/outer segment (IS/OS) interface status, and lesion reflectivity on SD-OCT determined no VA changes (P>.05), while their worsening determined a reduction of VA (P=.03). In eyes that presented a progression of the disease stage, mean central macular thickness, maximal thickness of the lesion, and maximal width of the lesion showed a significant change (from 404.1 ± 107.6 μm to 246.1 ± 74.0 μm, P = .004; from 277.0 ± 80.8 μm to 105.3 ± 92.3 μm, P=.001; from 2324.2 ± 1250.3 μm to 1751.0 ± 858.3 μm, P = .04, respectively). CONCLUSIONS: In adult-onset foveomacular vitelliform dystrophy, progression of the lesion stage (partial/complete resorption of the material) is generally accompanied by IS/OS interface disruption/loss and visual impairment. |
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Authors:
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Giuseppe Querques; Raimondo Forte; Lea Querques; Nathalie Massamba; Eric H Souied |
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Publication Detail:
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Type: Journal Article Date: 2011-06-12 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 152 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-25 Completed Date: 2011-09-15 Revised Date: 2012-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 304-13 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil, University Paris XII, Creteil, France. giuseppe.querques@hotmail.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Disease Progression Female Follow-Up Studies Humans Male Middle Aged Ophthalmoscopy Retinal Photoreceptor Cell Inner Segment / physiology* Retinal Photoreceptor Cell Outer Segment / physiology* Retrospective Studies Tomography, Optical Coherence* Vision Disorders / physiopathology* Visual Acuity / physiology Vitelliform Macular Dystrophy / physiopathology* |
| Comments/Corrections | |
Comment In:
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Am J Ophthalmol. 2012 Feb;153(2):389; author reply 389-90
[PMID:
22264960
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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