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Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity.
MedLine Citation:
PMID:  25429559     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Antimicrobial natural preparations involving cinnamon, storax and propolis have been long used topically for treating infections. Cinnamic acids and related molecules are partly responsible for the therapeutic effects observed in these preparations. Most of the cinnamic acids, their esters, amides, aldehydes and alcohols, show significant growth inhibition against one or several bacterial and fungal species. Of particular interest is the potent antitubercular activity observed for some of these cinnamic derivatives, which may be amenable as future drugs for treating tuberculosis. This review intends to summarize the literature data on the antimicrobial activity of the natural cinnamic acids and related derivatives. In addition, selected hybrids between cinnamic acids and biologically active scaffolds with antimicrobial activity were also included. A comprehensive literature search was performed collating the minimum inhibitory concentration (MIC) of each cinnamic acid or derivative against the reported microorganisms. The MIC data allows the relative comparison between series of molecules and the derivation of structure-activity relationships.
Authors:
Juan David Guzman
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Publication Detail:
Type:  REVIEW     Date:  2014-11-25
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  19     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  19292-19349     Citation Subset:  -    
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