Document Detail


Natural Autoantibodies and Associated B Cells in Immunity and Autoimmunity.
MedLine Citation:
PMID:  23186367     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A substantial proportion of circulating antibodies in healthy individuals exhibit self-reactivity. These antibodies, referred to as natural autoantibodies, are thought to arise naturally without actual antigen stimulation as they are present in human cord blood and in mice housed in germfree conditions and fed an antigen-free diet. Natural autoantibodies are mainly of the IgM class, unmutated, and typically polyreactive. They provide critical early protection against pathogens, and play important roles in maintenance of homeostasis and modulation of innate and adaptive immune responses, thereby conferring protection from rampant autoimmune and inflammatory injuries. In this review, we summarize current information regarding the properties of natural autoantibodies and the B cells that produce them, their roles in immunity and autoimmunity, their mechanisms of action, and their therapeutic potential.
Authors:
Kaiissar Mannoor; Yang Xu; Ching Chen
Related Documents :
21970317 - Development of an indirect competitive enzyme-linked immunosorbent assay applied to the...
24009787 - A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune...
23410987 - Enhanced transcutaneous immunization via dissolving microneedle array loaded with lipos...
24867307 - Presymptomatic autoantibodies in sjögren's syndrome: what significance do they hold fo...
3220797 - Microwave-stimulated incubation in immunoelectron microscopy: a quantitative study.
8756397 - Production, purification and characterization of an anti-(carcinoembryonic antigen) rec...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Autoimmunity     Volume:  -     ISSN:  1607-842X     ISO Abbreviation:  Autoimmunity     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pathology, University of Maryland School of Medicine , Baltimore, Maryland , USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enhancing the Analytical Selectivity of Voltammetric Technique by the Combination of Harmonic Analys...
Next Document:  A Theoretical Study on the Formation and Photolysis of Nitrosamines (CH(3)CH(2)NHNO and (CH(3)CH(2))...