| The natural 13C abundance of plasma glucose is a useful biomarker of recent dietary caloric sweetener intake. | |
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MedLine Citation:
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PMID: 20018804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is a need for objective biomarkers of dietary intake, because self-reporting is often subject to bias. We tested the validity of a biomarker for the fraction of dietary carbohydrate (CHO) from cane sugar and high fructose corn syrup (C(4) sugars) using natural (13)C abundance of plasma glucose. In a randomized, single-blinded, crossover design, 5 participants consumed 3 weight-maintaining diets for 7 d, with a 2-wk washout between diet periods. Diets differed in the fraction of total CHO energy from C(4) sugars (5, 16, or 32%). During each diet period, blood samples were drawn at hours 0800 and 1600 on d 1, 3, and 5 and at 0800, 1000, 1200, 1400, and 1600 on d 7. The delta(13)C abundance of plasma glucose was analyzed via GC- isotope ratio MS. Within each diet period, delta(13)C abundance of the 0800 fasting glucose did not change from baseline with increasing time during a diet period; however, there was a strong positive correlation (R(2) = 0.89) between delta(13)C abundance of the glucose concentration at 1000 on d 7 and the percent of breakfast CHO from C(4) sugars. Also, delta(13)C abundance of the combined plasma glucose samples on d 7 demonstrated a strong positive correlation (R(2) = 0.90) with the percent of total daily CHO from C(4) sugars. The natural delta(13)C abundance of postprandial plasma glucose relative to dietary C(4) CHO content was a valid biomarker for contributions of C(4) caloric sweeteners from the previous meal. |
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Authors:
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Chad M Cook; Amy L Alvig; Yu Qiu David Liu; Dale A Schoeller |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies Date: 2009-12-16 |
Journal Detail:
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Title: The Journal of nutrition Volume: 140 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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University of Wisconsin, Interdepartmental Graduate Program in Nutritional Science, Madison, WI 53706, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Blood Glucose / analysis*, chemistry Carbon Isotopes / analysis* Cross-Over Studies Diet* Dietary Sucrose / administration & dosage*, blood Energy Intake* Female Humans Male Postprandial Period Saccharum Single-Blind Method Young Adult Zea mays |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/Carbon Isotopes; 0/Dietary Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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