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Natriuretic peptides: prediction of cardiovascular disease in the general population and high risk populations.
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MedLine Citation:
PMID:  19773612     Owner:  NLM     Status:  MEDLINE    
The natriuretic peptides, especially the B-type peptide (BNP) and its inactive split-product N-terminal proBNP (Nt-proBNP) are increasingly used in screening for heart failure, primarily with reduced systolic function, in patients with symptoms suggestive of heart failure, as well in the stable (General Practitioner) setting as in the acute setting. Supporting this use is a very strong prognostic value of the natriuretic peptides. This has been shown in as well heart failure as acute coronary syndromes, but also in the general population and in high-risk groups as patients with diabetes, hypertension and coronary artery disease. This has of course raised interest for the use of the natriuretic peptides as a risk marker and for screening for heart failure with reduced systolic function in these populations. In symptomatic persons and in high risk populations, the natriuretic peptides have demonstrated a high sensitivity for ruling out the disease, if the right decision limits are choosen. Thus the number of normal echocardiographies can be reduced. More recently, the use in screening asymptomatic persons for left ventricular systolic dysfunction has gained more interest. In the unselected population, screening would probably not be cost-effective. In populations with a higher pre-test probability for heart failure, as patients with diabetes, hypertension and stable coronary artery disease, screening would presumably be more cost-effective, but evidence for the use in this setting is still lacking.
Per Hildebrandt
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Disease markers     Volume:  26     ISSN:  1875-8630     ISO Abbreviation:  Dis. Markers     Publication Date:  2009  
Date Detail:
Created Date:  2009-09-23     Completed Date:  2009-12-17     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  8604127     Medline TA:  Dis Markers     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood*
Cardiovascular Diseases / blood*,  diagnosis
Natriuretic Peptides / blood*
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Natriuretic Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Dis Markers
Journal ID (iso-abbrev): Dis. Markers
Journal ID (publisher-id): DM
ISSN: 0278-0240
ISSN: 1875-8630
Publisher: IOS Press
Article Information
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Copyright © 2009 Hindawi Publishing Corporation.
Received Day: 15 Month: 9 Year: 2009
Accepted Day: 15 Month: 9 Year: 2009
Print publication date: Year: 2009
Electronic publication date: Day: 21 Month: 9 Year: 2009
Volume: 26 Issue: 5-6
First Page: 227 Last Page: 233
PubMed Id: 19773612
ID: 3833235
Article Id: 837256
DOI: 10.3233/DMA-2009-0632

Natriuretic Peptides: Prediction of Cardiovascular Disease in the General Population and High Risk Populations
Per HildebrandtI1*
Section of CardiologyGlostrup University HospitalDenmark
Correspondence: *Per Hildebrandt:

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Keywords: Brain natriuretic peptide, cardiovascular disease, general population, prognosis, heart failure.

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