| Natriuretic peptides - physiology, pathophysiology and clinical use in heart failure. | |
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MedLine Citation:
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PMID: 18380534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The natriuretic peptides - atrial, brain and C-type - were discovered during the last twenty years. Their effects on cardiovascular, renal, cerebral and other tissues through guanylyl cyclase were uncovered. Over the past decade natriuretic peptides (NPs) became a very useful tool in the management of heart failure patients. Results of many clinical trials have shown that BNP and NT-proBNP are helpful for diagnosis of heart failure. They are also independent markers of prognosis not only in heart failure patients but also in patients with other cardiovascular diseases. Recently published data document the utility of NPs in guiding treatment of heart failure patients. In this article, we focus on basic biochemical and physiological characteristics of NPs as well as on their significance in management of heart failure patients. Some limitations and pitfalls of NPs levels interpretation in diagnosing heart failure are also discussed. |
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Authors:
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J Krupicka; T Janota; Z Kasalová; J Hradec |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-04-01 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 58 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-06-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 171-7 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, General University Hospital in Prague, Prague, Czech Republic. j.krupicka@centrum.cz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Heart Failure
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drug therapy*,
physiopathology* Humans Natriuretic Peptides / physiology*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Natriuretic Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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