Document Detail

Natriuretic peptides in patients with atrial fibrillation.
MedLine Citation:
PMID:  19039756     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of the study was to evaluate plasma natriuretic peptides (NPs): atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations in patients with paroxysmal, persistent and permanent atrial fibrillation (AF). METHODS AND RESULTS: The study groups consisted of 23 patients with paroxysmal AF, 42 patients with permanent AF and 77 patients with persistent AF with normal left ventricular function. The mean ANP level was increased in AF patients in the paroxysmal, persistent and permanent groups: 249 +/- 88.3 pg/mL; 258 +/- 89.7 pg/mL; 208 +/- 76.7 pg/mL, respectively, vs. 67 +/- 21.2 pg/mL in the control subjects (p < 0.001). The mean BNP level was increased in AF patients in the paroxysmal, persistent and permanent groups: 99.6 +/- 29.8 pg/mL; 82.3 +/- 33 pg/mL; 95.6 +/- 46.4 pg/mL, respectively, vs. 37.5 +/- 13 pg/mL in the control group. Multivariate logistic regression analysis revealed a positive correlation between ANP levels, maximal left atrial volume, heart rate and New York Heart Association (NYHA) classification, in the persistent AF patients. A positive correlation between plasma BNP levels and heart failure stage according to NYHA classification in this group was found. Baseline ANP concentrations were positively correlated with baseline BNP concentrations in AF patients. CONCLUSIONS: Plasma NPs levels are increased in patients with paroxysmal, persistent and permanent AF and normal left ventricle function, and positively correlated with left atrial volume, heart rate and heart failure stage according to NYHA classification. Neurohormonal assessment does not distinguish the type of arrhythmia.
Beata Wozakowska-Kapłon; Grzegorz Opolski; Zbigniew Herman; Dariusz Kosior
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiology journal     Volume:  15     ISSN:  1897-5593     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  525-9     Citation Subset:  IM    
Department of Cardiology Regional District Hospital, Institute for Medical Education, University of Kielce, Poland.
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MeSH Terms
Atrial Fibrillation / blood*,  physiopathology
Atrial Natriuretic Factor / blood
Biological Markers / blood
Disease Progression
Electrocardiography, Ambulatory
Follow-Up Studies
Middle Aged
Natriuretic Peptide, Brain / blood
Natriuretic Peptides / blood*
Prospective Studies
Stroke Volume / physiology
Reg. No./Substance:
0/Biological Markers; 0/Natriuretic Peptides; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

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