| Natriuretic peptides in cardiovascular diseases of fetus, infants and children. | |
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MedLine Citation:
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PMID: 19149543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The natriuretic peptides (NP) appear to be functional by midgestation, respond to volume stimuli, and regulate blood pressure and salt and water balance in the developing embryo. In addition, the NP may help regulate the blood supply to the fetus, acting as vasodilators in the placental vasculature. Peaks of ANP and BNP expression during gestation coincide with significant events in cardiac organogenesis, suggesting a role for NP in the formation of the heart. Levels of atrial natriuretic peptide (ANP) are higher in the fetal circulation than in adults, and fetal ventricles express higher levels of ANP and B-type natriuretic peptide (BNP) than adult ventricles. In this comprehensive review we have discussed the role NP during development of the fetal heart and circulation and in various cardiovascular diseases of neonatal and pediatric age group. |
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Authors:
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Bibhuti B Das; Shashi Raj; Robert Solinger |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular & hematological agents in medicinal chemistry Volume: 7 ISSN: 1875-6182 ISO Abbreviation: - Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266881 Medline TA: Cardiovasc Hematol Agents Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 43-51 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Pediatrics, University of Louisville, 571 S Floyd Street, Louisville, KY 40202, USA. bdas99@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Circulation Cardiovascular Diseases* Cardiovascular System* / embryology, growth & development Child Female Fetus Heart / embryology, growth & development Humans Infant Infant, Newborn Natriuretic Peptides / physiology* Organogenesis Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Natriuretic Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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