Document Detail


Natriuretic peptides in acute chest pain and acute coronary syndrome: from pathophysiology to clinical and prognostic applications.
MedLine Citation:
PMID:  23164752     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Plasma levels of natriuretic peptides (NPs) appear to have an important prognostic value in many clinical settings including coronary artery disease and provide additional information about cardiovascular risk. CONTENT: The aim of this study was to review the literature on the role of NPs in the prognosis and management of patients with acute chest pain and acute coronary syndrome (ACS). Several trials have assessed the prognostic value of NPs as biomarkers of myocardial injury for risk stratification in patients with acute chest pain and ACS. The additional prognostic information on measurement of NP levels is independent of that provided by cardiac troponin and the various clinical and ECG features and traditional risk markers available at hospital admission. CONCLUSION: Although measurement of the level of NPs is not recommended as a diagnostic tool in ACS management, their concentrations seem to distinguish patients at a higher risk not only for heart failure but also for ACS. NPs are a good risk marker for ACS, in addition to troponins, but have not yet been proved suitable for guiding therapy.
Authors:
Nadia Aspromonte; Stefania A Di Fusco; Roberto Latini; Dinna N Cruz; Serge Masson; Marco Tubaro; Alberto Palazzuoli
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-15
Journal Detail:
Title:  Coronary artery disease     Volume:  -     ISSN:  1473-5830     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aCardiovascular Department, San Filippo Neri Hospital, Rome bDepartment of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan cDepartment of Nephrology, Dialysis and Transplantation and International Renal Research Institute Vicenza (IRRIV), San Bortolo Hospital, Vicenza, dDepartment of Internal Medicine and Metabolic Diseases, Cardiology Section, University of Siena, Siena, Italy.
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