Document Detail


Natriuretic peptides as prognostic and diagnostic markers in Chagas' disease.
MedLine Citation:
PMID:  15837529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atrial natriuretic factor (ANF) is a hormone secreted predominantly from atrial myocardium in response to changes in wall tension. Chagas' disease is caused by the parasite Trypanosom cruzi (T. cruzi), the heart being one of the most affected organs, resulting in myocarditis and chronic cardiomyopathy. The inflammatory response of the myocardium may be the result of factors such as ischemia, direct parasite invasion, and autoimmune mechanisms. In this review, we discuss the current knowledge about ANF in Chagas' disease and describe our findings in studying: (1) the development of chagasic cardiomyophathy in T. cruzi-infected rats and its relationship with plasma ANF levels; (2) the evolution of plasma ANF in chagasic patients in different stages (asymptomatic, with conduction defects and with chronic heart failure [CHF]); and (3) the possible usefulness of plasma ANF as a prognostic factor of development of myocardial compromise and survival. In rats, the elevated ANF levels found could mirror the inflammatory response of myocardial cells to acute T. cruzi infection and of progressive failure of cardiac function in the chronic infection. In patients, plasma ANF could be a sensitive marker capable of detecting gradual impairments in cardiac function and poor survival in CHF patients and of myocardiopathy development in the asymptomatic state.
Authors:
Ana M Puyó; Jorge Scaglione; Sergio Auger; Susana Cavallero; Miriam Postan; Belisario E Fernández
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Regulatory peptides     Volume:  128     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2005-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Affiliation:
Cátedra de Anatomía Macro y Microscópica, Universidad de Buenos Aires, Junín 956, (1113) Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / analysis
Cardiomyopathies / parasitology
Chagas Disease / diagnosis*,  pathology,  physiopathology*
Disease Models, Animal
Humans
Myocarditis / parasitology
Natriuretic Peptides / analysis*
Prognosis
Rats
Trypanosoma cruzi
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Natriuretic Peptides

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