Document Detail

Natriuretic peptide responses to acute and chronic ventricular pacing in sheep.
MedLine Citation:
PMID:  8779835     Owner:  NLM     Status:  MEDLINE    
The responses of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) were investigated in six conscious sheep paced at 120, 155, 190, and 225 beats/min for 1.5 h at each rate and at 180, 225, and 180 beats/min for 4 days at each rate. Increased pacing reduced arterial pressure, cardiac output, and urine and Na excretion and increased left atrial pressure and plasma ANP, BNP, and C-type natriuretic peptide, with delayed activation of the renin-angiotensin system (RAS). Acute pacing increased plasma ANP and BNP levels 8.6- and 3.6-fold, respectively (both P < 0.001), whereas chronic pacing increased ANP and BNP 7.8- and 9-fold, respectively (both P < 0.001). Thus the ANP-to-BNP ratio increased during acute pacing (P < 0.001) and decreased proportionately during chronic pacing (P < 0.05). Reduction in pacing improved hemodynamic status, reduced natriuretic peptides (BNP less than ANP), normalized the RAS, and induced diuresis and natriuresis. In conclusion, BNP is less responsive than ANP to acute changes in intracardiac pressure but is proportionately more responsive to chronic hemodynamic changes such as occur in congestive heart failure.
M T Rademaker; C J Charles; E A Espiner; C M Frampton; M G Nicholls; A M Richards
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  270     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-20     Completed Date:  1996-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H594-602     Citation Subset:  IM    
Department of Medicine, Christchurch School of Medicine, New Zealand.
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MeSH Terms
Atrial Natriuretic Factor / blood*
Cardiac Pacing, Artificial*
Heart Failure / blood,  physiopathology
Natriuretic Peptide, Brain
Natriuretic Peptide, C-Type
Nerve Tissue Proteins / blood*
Proteins / metabolism*
Renin-Angiotensin System
Sheep / blood
Time Factors
Ventricular Function, Left*
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/Proteins; 114471-18-0/Natriuretic Peptide, Brain; 127869-51-6/Natriuretic Peptide, C-Type; 85637-73-6/Atrial Natriuretic Factor

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