Document Detail

Natriuretic peptides in systemic sclerosis-related pulmonary arterial hypertension.
MedLine Citation:
PMID:  19539354     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Systemic sclerosis-related pulmonary arterial hypertension (SSc PAH) is a major complication of both limited and diffuse systemic sclerosis and leads to substantial morbidity and mortality. Natriuretic peptides (NP) are clinically useful markers of right ventricular dysfunction and pulmonary hypertension. The aim of our review was to examine the evidence for the physiologic, diagnostic, and prognostic role of NP in the context of SSc PAH. METHODS: A Medline search for articles published between January 1999 and December 2008 was conducted using the following keywords: natriuretic peptides, systemic sclerosis or scleroderma, and pulmonary arterial hypertension. RESULTS: In patients with SSc PAH, NP levels increase in proportion to the extent of right ventricular dysfunction and correlate significantly with functional capacity and echocardiographic and hemodynamic parameters. NP may also provide prognostic information beyond conventional risk markers but their use has to be considered against the background of the parameters that may influence their concentration. CONCLUSION: There is growing evidence that NP, along with the traditional assessment modalities such as echocardiography and the 6-minute walking test, may be a suitable marker for SSc PAH in terms of screening, diagnostic evaluation, risk stratification, and response to therapy; this merits prospective evaluation.
Theodoros Dimitroulas; Georgios Giannakoulas; Haralambos Karvounis; Michael A Gatzoulis; Loucas Settas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-17
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  39     ISSN:  1532-866X     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-84     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
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MeSH Terms
Biological Markers / blood
Hypertension, Pulmonary / blood*,  etiology*
Natriuretic Peptides / blood*
Scleroderma, Systemic / blood*,  complications*
Severity of Illness Index
Grant Support
//British Heart Foundation
Reg. No./Substance:
0/Biological Markers; 0/Natriuretic Peptides

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