| Native plasma kallikrein is cleared at similar rates by mammalian and avian livers. | |
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MedLine Citation:
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PMID: 1823219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat plasma kallikrein (RPK) is a serine protease that circulates as an inactive precursor, prokallikrein, and once activated is efficiently cleared by the liver by a carbohydrate-dependent, Ca(2+)-independent mechanism. Seven hepatic lectin systems have been described for mammals but not all of these animal lectins are expressed in the avian liver. Using a liver perfusion system we compared the plasma kallikrein clearance of rats (N = 10) and pigeons (N = 4). Our results show that the lectin responsible for the hepatic clearance of plasma kallikrein is also present in pigeon liver and that this organ clears the enzyme with an efficiency (11.4 +/- 1.3 pmol/g, 20 min) similar to that of the rat liver (10.0 +/- 0.7 pmol/g, 20 min). |
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Authors:
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D R Borges; M Kouyoumdjian; E A Limãos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 24 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-09-22 Completed Date: 1992-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 63-5 Citation Subset: IM |
Affiliation:
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Disciplina de Gastroenterologia Clínica, Escola Paulista de Medicina, São Paulo, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Columbidae Kallikreins / blood*, metabolism Liver / metabolism* Metabolic Clearance Rate Rats Receptors, Mitogen Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Mitogen; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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