Document Detail


Nationwide outbreak of listeriosis due to contaminated meat.
MedLine Citation:
PMID:  16318652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used molecular subtyping to investigate an outbreak of listeriosis involving residents of 24 US states. We defined a case as infection with Listeria monocytogenes serotype 4b yielding one of several closely related patterns when subtyped by pulsed-field gel electrophoresis. Patients infected with strains yielding different patterns were used as controls. A total of 108 cases were identified with 14 associated deaths and four miscarriages or stillbirths. A case-control study implicated meat frankfurters as the likely source of infection (OR 17.3, 95% CI 2.4-160). The outbreak ended abruptly following a manufacturer-issued recall, and the outbreak strain was later detected in low levels in the recalled product. A second strain was recovered at higher levels but was not associated with human illness. Our findings suggest that L. monocytogenes strains vary widely in virulence and confirm that large outbreaks can occur even when only low levels of contamination are detected in sampled food. Standardized molecular subtyping and coordinated, multi-jurisdiction investigations can greatly facilitate detection and control of listeriosis outbreaks.
Authors:
P S Mead; E F Dunne; L Graves; M Wiedmann; M Patrick; S Hunter; E Salehi; F Mostashari; A Craig; P Mshar; T Bannerman; B D Sauders; P Hayes; W Dewitt; P Sparling; P Griffin; D Morse; L Slutsker; B Swaminathan;
Publication Detail:
Type:  Journal Article     Date:  2005-12-01
Journal Detail:
Title:  Epidemiology and infection     Volume:  134     ISSN:  0950-2688     ISO Abbreviation:  Epidemiol. Infect.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-06-27     Completed Date:  2006-08-31     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8703737     Medline TA:  Epidemiol Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  744-51     Citation Subset:  IM    
Affiliation:
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. pmead@cdc.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Animals
Child
Child, Preschool
Disease Outbreaks*
Electrophoresis, Gel, Pulsed-Field
Female
Food Contamination*
Food Microbiology
Foodborne Diseases / epidemiology*,  microbiology*
Humans
Listeria monocytogenes / isolation & purification*
Listeriosis / epidemiology*,  microbiology*
Male
Meat / microbiology*
Middle Aged
Pregnancy
United States / epidemiology
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Confounding factors in the detection of species responses to habitat fragmentation.
Next Document:  An outbreak of hepatitis A in Southern Italy: the case for vaccinating food handlers.