| National surveillance of emergency department visits for outpatient adverse drug events in children and adolescents. | |
| | |
MedLine Citation:
|
PMID: 18280852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To describe the national scope and magnitude of outpatient adverse drug events (ADEs) that lead to emergency department (ED) visits in children and adolescents. STUDY DESIGN: To conduct an active surveillance of patients 18 years of age or younger who came to EDs with ADEs from Jan 1, 2004, to Dec 31, 2005, through a nationally representative, stratified probability sample of 63 US hospitals with EDs. The main outcome measures were national estimates of the number, type, patient demographics, and clinical characteristics of ADEs. RESULTS: Annually, an estimated 158,520 patients </=18 years old (95% CI, 117,745-199,295; 2 per 1000 persons) were treated in EDs for ADEs. Almost half (49.4%) of these visits occurred in patients between 1 and 4 years of age. Unintentional overdoses were the most common type of ADE (44.9%), followed by allergic reactions (35%), and adverse effects (12.6%). Antimicrobial agents, analgesic medications, and respiratory medications accounted for almost half of ADEs (25.2%, 13.7%, and 10.6%, respectively). Fewer than 1 in 10 patients (9.5%) required hospitalization or extended observation. CONCLUSIONS: Interventions targeting unintentional overdoses of medications commonly given to preschool-aged children would likely have the highest impact in reducing ED visits from outpatient ADEs. |
| | |
Authors:
|
Adam L Cohen; Daniel S Budnitz; Kelly N Weidenbach; Daniel B Jernigan; Thomas J Schroeder; Nadine Shehab; Daniel A Pollock |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-22 |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 152 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-02-18 Completed Date: 2008-03-18 Revised Date: 2008-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 416-21 Citation Subset: AIM; IM |
Affiliation:
|
Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adverse Drug Reaction Reporting Systems Age Factors Child Child, Preschool Confidence Intervals Cross-Sectional Studies Drug Hypersensitivity / epidemiology, etiology* Drug Toxicity / diagnosis, epidemiology* Emergency Service, Hospital / utilization* Female Hospitalization / statistics & numerical data* Humans Incidence Male Probability Risk Factors Sex Factors Survival Rate United States |
| Comments/Corrections | |
Comment In:
|
J Pediatr. 2008 Mar;152(3):A2
[PMID:
18280822
]
|
Erratum In:
|
J Pediatr. 2008 Jun;152(6):893 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Medication use in the neonatal intensive care unit: current patterns and off-label use of parenteral...
Next Document: Patients with cartilage-hair hypoplasia have an increased risk for bronchiectasis.