Document Detail

National review of first treatment change after starting highly active antiretroviral therapy in antiretroviral-naïve patients.
MedLine Citation:
PMID:  17461863     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of the study was to explore the factors surrounding modification of the first antiretroviral (ARV) regimen where drug switch occurred 3 months or more after initiation. Reference was made to the British HIV Association (BHIVA) guidelines on HIV management. METHODS: A case note and questionnaire-based audit was carried out. RESULTS: Toxicity was the single most important reason for ARV change and was the only, or a contributory, cause in over half the patients. Virological failure, adherence issues, requirement for treatment simplification, and patient request were other significant reasons cited. In one-third of those with virological failure, six or more months had elapsed between first detection and the time of switching to a new ARV regimen. CONCLUSIONS: This audit demonstrated broad adherence to the BHIVA guidelines, although the long time before switching ARVs in the setting of virological failure was of some concern, particularly given the continuing and significant occurrence of primary ARV resistance in the UK.
E Hart; H Curtis; E Wilkins; M Johnson
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  HIV medicine     Volume:  8     ISSN:  1464-2662     ISO Abbreviation:  HIV Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897392     Medline TA:  HIV Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
North Manchester General Hospital, Manchester, UK.
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MeSH Terms
Anti-HIV Agents / administration & dosage,  adverse effects
Antiretroviral Therapy, Highly Active / adverse effects,  methods*
Great Britain
HIV / growth & development*
HIV Infections / drug therapy*,  virology
Practice Guidelines as Topic
Viral Load
Reg. No./Substance:
0/Anti-HIV Agents

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