| National review of first treatment change after starting highly active antiretroviral therapy in antiretroviral-naïve patients. | |
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MedLine Citation:
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PMID: 17461863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of the study was to explore the factors surrounding modification of the first antiretroviral (ARV) regimen where drug switch occurred 3 months or more after initiation. Reference was made to the British HIV Association (BHIVA) guidelines on HIV management. METHODS: A case note and questionnaire-based audit was carried out. RESULTS: Toxicity was the single most important reason for ARV change and was the only, or a contributory, cause in over half the patients. Virological failure, adherence issues, requirement for treatment simplification, and patient request were other significant reasons cited. In one-third of those with virological failure, six or more months had elapsed between first detection and the time of switching to a new ARV regimen. CONCLUSIONS: This audit demonstrated broad adherence to the BHIVA guidelines, although the long time before switching ARVs in the setting of virological failure was of some concern, particularly given the continuing and significant occurrence of primary ARV resistance in the UK. |
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Authors:
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E Hart; H Curtis; E Wilkins; M Johnson |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: HIV medicine Volume: 8 ISSN: 1464-2662 ISO Abbreviation: HIV Med. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-27 Completed Date: 2007-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100897392 Medline TA: HIV Med Country: England |
Other Details:
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Languages: eng Pagination: 186-91 Citation Subset: IM |
Affiliation:
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North Manchester General Hospital, Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-HIV Agents
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administration & dosage,
adverse effects Antiretroviral Therapy, Highly Active / adverse effects, methods* Great Britain HIV / growth & development* HIV Infections / drug therapy*, virology Humans Practice Guidelines as Topic Viral Load |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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