Document Detail


National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006.
MedLine Citation:
PMID:  20920770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The national prevalence and patterns of food allergy (FA) in the United States are not well understood.
OBJECTIVE: We developed nationally representative estimates of the prevalence of and demographic risk factors for FA and investigated associations of FA with asthma, hay fever, and eczema.
METHODS: A total of 8203 participants in the National Health and Nutrition Examination Survey 2005-2006 had food-specific serum IgE measured to peanut, cow's milk, egg white, and shrimp. Food-specific IgE and age-based criteria were used to define likely FA (LFA), possible FA, and unlikely FA and to develop estimates of clinical FA. Self-reported data were used to evaluate demographic risk factors and associations with asthma and related conditions.
RESULTS: In the United States, the estimated prevalence of clinical FA was 2.5% (peanut, 1.3%; milk, 0.4%; egg, 0.2%; shrimp, 1.0%; not mutually exclusive). Risk of possible FA/LFA was increased in non-Hispanic blacks (odds ratio, 3.06; 95% CI, 2.14-4.36), males (1.87; 1.32-2.66), and children (2.04; 1.42-2.93). Study participants with doctor-diagnosed asthma (vs no asthma) exhibited increased risk of all measures of food sensitization. Moreover, in those with LFA, the adjusted odds ratio for current asthma (3.8; 1.5-10.7) and an emergency department visit for asthma in the past year (6.9; 2.4-19.7) were both notably increased.
CONCLUSION: Population-based serologic data on 4 foods indicate an estimated 2.5% of the US population has FA, and increased risk was found for black subjects, male subjects, and children. In addition, FA could be an under-recognized risk factor for problematic asthma.
Authors:
Andrew H Liu; Renee Jaramillo; Scott H Sicherer; Robert A Wood; S Allan Bock; A Wesley Burks; Mark Massing; Richard D Cohn; Darryl C Zeldin
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-11-12     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  798-806.e13     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Affiliation:
National Jewish Health and University of Colorado Denver School of Medicine, Denver, CO, USA. liua@njhealth.org
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Allergens / adverse effects
Asthma / complications,  epidemiology*
Child
Child, Preschool
Eczema / complications,  epidemiology
Female
Food / adverse effects
Food Hypersensitivity / complications,  epidemiology*,  etiology
Humans
Immunoglobulin E / blood
Infant
Male
Middle Aged
Nutrition Surveys
Prevalence
Rhinitis, Allergic, Seasonal / complications,  epidemiology
Risk Factors
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
Z01 ES025041-11/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E
Comments/Corrections

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