| National birth rate, IVF utilisation and multiple gestation trends: findings from a 6-year analysis in the Republic of Ireland. | |
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MedLine Citation:
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PMID: 20464406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The impact of the advanced reproductive technologies on multiple gestation has been well documented in several large populations, but only infrequently in smaller countries, where its effects may be different. This study estimated domestic in vitro fertilisation (IVF) use and multiple gestation rate in Ireland based on two data-reporting platforms. METHODS: The number of IVF cycles completed in Ireland was extrapolated from statistics reported to the central European fertility registry (ESHRE) between 1999 and 2004. Multiple gestation data during this period were obtained from the National Perinatal Reporting System (NPRS). These datasets were interlocked to offer a method to track the impact of IVF activity on background multiple gestation rate in Ireland. RESULTS: Total Irish births registered increased from 54,307 in 1999 to 62,406 in 2004, and multiple gestation rate (per 1,000) fluctuated non-linearly from 27.2 to 31.4 during this time. Reported IVF activity increased from 972 in 1999 to 1,705 in 2004. Annual incidence of multiple gestation appeared strongly correlated with annual number of ETs although statistical significance was not reached (unadjusted Spearman correlation coefficient = 0.6; p = 0.21). CONCLUSION: Although IVF providers must continue to reduce multiple births by limiting the number of embryos transferred, this study places national IVF activity in the context of multiple gestations recorded in the general Irish population. These datasets suggest the number of patients undergoing IVF increased steadily in Ireland from 1999 to 2004, but a similar increase in multiple gestation was not observed in the overall Irish population during our study interval. While it is reassuring that increased use of IVF in Ireland did not significantly influence the multiple gestation rate, the absence of a formal data collection method hampers direct and comprehensive monitoring of this phenomenon here. |
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Authors:
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Eric Scott Sills; David J Walsh; Ahmed B Omar; Umme Salma; Anthony P H Walsh |
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Publication Detail:
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Type: Journal Article Date: 2010-05-13 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 282 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 221-4 Citation Subset: IM |
Affiliation:
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The Sims Institute/Sims International Fertility Clinic, Rosemount Hall, Dundrum Road, Dundrum, Dublin 14, Ireland. drscottsills@sims.ie |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Rate / trends* Female Fertilization in Vitro / trends*, utilization* Humans Ireland / epidemiology Maternal Age Multiple Birth Offspring / statistics & numerical data* Pregnancy Pregnancy, Multiple / statistics & numerical data* Registries / statistics & numerical data |
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